Document Detail

Optic nerve hypoplasia and growth hormone deficiency in a cholestatic infant.
MedLine Citation:
PMID:  16638511     Owner:  NLM     Status:  MEDLINE    
This report describes a 4-month-old male with cholestasis, hypoglycemia, and short stature. Symptoms appeared since neonatal age with jaundice, hypoglycemia, neurologic manifestations, and later with short stature. Laboratory investigation was indicative for cholestasis. Further research indicated isolated growth hormone deficiency with accompanying optic nerve hypoplasia. Unexplained hypoglycemia and cholestasis in neonates have to be investigated for growth hormone deficiency. Moreover, in cases with unexplained cholestasis, timely recognition of hypoglycemia is important for the early diagnosis of the disorder before the appearance of growth retardation.
Ioannis Xinias; Maria Papadopoulou; Theodouli Papastavrou; Kaliopi Patsiaoura; Kleomenis Spiroglou
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  34     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-26     Completed Date:  2006-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319-22     Citation Subset:  IM    
Third Department of Paediatrics, Hippocration University Hospital, Thessaloniki, Greece.
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MeSH Terms
Cholestasis / etiology*
Human Growth Hormone / deficiency*
Hypoglycemia / etiology*
Hypopituitarism / complications*,  congenital,  diagnosis*
Optic Nerve / abnormalities*
Reg. No./Substance:
12629-01-5/Human Growth Hormone

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