| Optic neuritis associated with adalimumab in the treatment of uveitis. | |
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MedLine Citation:
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PMID: 20809867 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Tumor necrosis factor (TNF) inhibitors such as adalimumab are increasingly used in the treatment of ocular inflammatory disease refractory to standard therapies. There is evidence that TNF inhibitors are associated with demyelinating neurologic events. OBJECTIVE: The authors report a case of optic neuritis and multiple sclerosis developing in association with the use of adalimumab for the treatment of bilateral chronic granulomatous iridocyclitis and multifocal choroiditis. They also review the available literature on cases of optic neuritis occurring in the setting of TNF inhibition. RESULTS: The authors identified 21 cases of optic neuritis associated with TNF inhibition; 36% of cases with available MRI results had evidence of other demyelinating lesions in the CNS. CONCLUSIONS: The strong association between TNF inhibitors and CNS demyelination may represent an adverse effect of these drugs. Ophthalmologists should recognize the relationship between TNF inhibitors and demyelinating disease, as it can present initially with visual symptoms. |
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Authors:
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Sing Your Li; Andrea D Birnbaum; Debra A Goldstein |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-01 |
Journal Detail:
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Title: Ocular immunology and inflammation Volume: 18 ISSN: 1744-5078 ISO Abbreviation: Ocul. Immunol. Inflamm. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312169 Medline TA: Ocul Immunol Inflamm Country: England |
Other Details:
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Languages: eng Pagination: 475-81 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, Illinois, USA. Singli03@gmail.com |
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| Comments/Corrections | |
Comment In:
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Ocul Immunol Inflamm. 2010 Dec;18(6):421-3
[PMID:
21091055
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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