Document Detail

Opsoclonus in a patient with Guillain-Barré syndrome.
MedLine Citation:
PMID:  1621500     Owner:  NLM     Status:  MEDLINE    
A 54 year-old woman showed the unusual association of a Guillain-Barré syndrome and opsoclonus, a rare eye movement characterized by involuntary bursts of jerking, ataxic and multidirectional saccades, without an intersaccadic interval. Since opsoclonus is a phenomenon described exclusively in CNS diseases, the case reported supports the hypothesis of CNS involvement in some cases of Guillain-Barré syndrome. The latter is generally considered an immune-mediated disease and an immune pathogenesis is also supposed in opsoclonus associated with systemic malignancies; besides, in the patient reported, the self-limiting nature of the disturbance and the lack of MRI lesions suggest that opsoclonus may result from an immune-related phenomenon causing a functional and transitory dysfunction of the CNS.
A Nicolai; L G Lazzarino
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  85     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-08-06     Completed Date:  1992-08-06     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  363-4     Citation Subset:  IM    
Department of Neurology, Ospedale Civile, Gorizia, Italy.
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MeSH Terms
Brain Stem / pathology
Central Nervous System Diseases / complications,  physiopathology
Eye Diseases / etiology,  pathology,  physiopathology
Eye Movements
Immune System Diseases / complications,  physiopathology
Immunoglobulin G / cerebrospinal fluid
Immunoglobulin M / cerebrospinal fluid
Middle Aged
Neural Conduction
Polyradiculoneuropathy / etiology,  physiopathology*
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin M

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