| Opposite influences of hypertension and diabetes mellitus on pressor responses induced by different alpha-adrenoceptor agonists and angiotensin II in pithed rats. | |
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MedLine Citation:
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PMID: 8777475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension is often present in the diabetic individual and it is known to aggravate the vascular complications associated with diabetes. The pressor responses to two alpha 1-adrenoceptor agonists (ST587 and cirazoline), two alpha 2-adrenoceptor agonists (azepexole dihydrochloride (B-HT933) and UK14.304) and angiotensin II were investigated in pithed spontaneously hypertensive rats (SHR) and in pithed normotensive Wistar Kyoto rats (WKY) made diabetic by a single i.v. injection (55 mg/kg) of streptozotocin (STZ). Two months after diabetes was induced, the effect of the agonists on basal diastolic blood pressure (DBP) was determined. In pithed diabetic WKY and SHR, the maximal pressor response was impaired for all agonists. The dose response curves were shifted to the right when compared with their non-diabetic controls. The hypertensive state enhanced the maximal pressor response to all agonists compared with non-hypertensive animals. Additional diabetes blunted this increase in the effects of ST587, B-HT933 and angiotensin II, but not in those of cirazoline and UK14.304. Hypertension caused a leftward shift of the dose response curve for ST587 when compared with the non-hypertensive state. However, this effect was not observed when diabetes was present as well. In conclusion, hypertension resulted in an enhanced pressor effect, possibly caused by vascular hypertrophy, whereas the diabetic state counteracted this effect. |
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Authors:
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O H Beenen; M J Mathy; M Pfaffendorf; P A van Zwieten |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood pressure Volume: 5 ISSN: 0803-7051 ISO Abbreviation: Blood Press. Publication Date: 1996 Jan |
Date Detail:
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Created Date: 1996-09-17 Completed Date: 1996-09-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9301454 Medline TA: Blood Press Country: NORWAY |
Other Details:
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Languages: eng Pagination: 57-63 Citation Subset: IM |
Affiliation:
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Department of Pharmacotherapy, University of Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology* Angiotensin II / pharmacology* Animals Azepines / pharmacology Blood Glucose / analysis Blood Pressure / drug effects* Clonidine / analogs & derivatives, pharmacology Decerebrate State Diabetes Mellitus, Experimental / complications, physiopathology* Dose-Response Relationship, Drug Hypertension / complications, physiopathology* Imidazoles / pharmacology Male Quinoxalines / pharmacology Rats Rats, Inbred SHR Rats, Inbred WKY |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Azepines; 0/Blood Glucose; 0/Imidazoles; 0/Quinoxalines; 11128-99-7/Angiotensin II; 15327-38-5/St 587; 36067-73-9/B-HT 933; 4205-90-7/Clonidine; 59803-98-4/brimonidine; 59939-16-1/cirazoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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