Document Detail

Opposite effects of gentle handling on body temperature and body weight in rats.
MedLine Citation:
PMID:  10549902     Owner:  NLM     Status:  MEDLINE    
Opposite effects of gentle handling on body temperature and body weight in rats. PHhe aim of this study was to measure the body weight set point when rats are being handled gently and thus experience emotional rise in body temperature. Wistar male rats were used in this experiment, and each rat was its own control. Body weight set point was estimated from the rat's food hoarding behavior. The set point is the intersection of the regression line for hoarding with the X axis. During hoarding sessions the experimenter handled the rat and took its colonic temperature six to eight times, an action sufficient to arouse emotional fever. On alternate days the rats were not handled. Thus, body weight set point was obtained for each rat without handling and with handling. In sessions with handling, rats raised their body temperature, ate less, and defecated more than in control sessions. When handled, the body weight set point declined from 388 +/- 44 g to 366 +/- 47 g (p = 0.048, t = 2,39). The decline in the set point induced by gentle handling is believed to result from an elevation of the hypothalamic CRH.
C Michel; M Cabanac
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  67     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-12-13     Completed Date:  1999-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  617-22     Citation Subset:  IM    
Département de physiologie, Faculté de médecine, Université Laval, Québec, Canada.
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MeSH Terms
Body Temperature / physiology*
Body Weight / physiology*
Corticotropin-Releasing Hormone / blood
Defecation / physiology
Emotions / physiology
Feeding Behavior / physiology
Fever / physiopathology,  psychology
Handling (Psychology)*
Rats, Wistar
Stress, Psychological / blood,  physiopathology*
Time Factors
Reg. No./Substance:
9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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