Document Detail

Opposing oncogenic activities of small DNA tumor virus transforming proteins.
MedLine Citation:
PMID:  21330137     Owner:  NLM     Status:  MEDLINE    
The E1A gene of species C human adenovirus is an intensely investigated model viral oncogene that immortalizes primary cells and mediates oncogenic cell transformation in cooperation with other viral or cellular oncogenes. Investigations using E1A proteins have illuminated important paradigms in cell proliferation and about the functions of cellular proteins such as the retinoblastoma protein. Studies with E1A have led to the unexpected discovery that E1A also suppresses cell transformation and oncogenesis. Here, I review our current understanding of the transforming and tumor-suppressive functions of E1A, and how E1A studies led to the discovery of a related tumor-suppressive function in benign human papillomaviruses. The potential role of these opposing functions in viral replication in epithelial cells is also discussed.
G Chinnadurai
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-02-15
Journal Detail:
Title:  Trends in microbiology     Volume:  19     ISSN:  1878-4380     ISO Abbreviation:  Trends Microbiol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-05     Completed Date:  2011-07-18     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  9310916     Medline TA:  Trends Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  174-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Adenoviridae / pathogenicity*
Adenovirus E1A Proteins / metabolism*
Oncogene Proteins, Viral / metabolism*
Tumor Suppressor Proteins / metabolism
Virulence Factors / metabolism
Grant Support
CA-033616/CA/NCI NIH HHS; CA-084941/CA/NCI NIH HHS; R01 CA033616/CA/NCI NIH HHS; R01 CA033616-29/CA/NCI NIH HHS; R01 CA084941/CA/NCI NIH HHS; R01 CA084941-09/CA/NCI NIH HHS
Reg. No./Substance:
0/Adenovirus E1A Proteins; 0/Oncogene Proteins, Viral; 0/Tumor Suppressor Proteins; 0/Virulence Factors

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