Document Detail

Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system.
MedLine Citation:
PMID:  15996548     Owner:  NLM     Status:  MEDLINE    
During development of the retinocollicular projection in mouse, retinal axons initially overshoot their future termination zones (TZs) in the superior colliculus (SC). The formation of TZs is initiated by interstitial branching at topographically appropriate positions. Ephrin-As are expressed in a decreasing posterior-to-anterior gradient in the SC, and they suppress branching posterior to future TZs. Here we investigate the role of an EphA7 gradient in the SC, which has the reverse orientation to the ephrin-A gradient. We find that in EphA7 mutant mice the retinocollicular map is disrupted, with nasal and temporal axons forming additional or extended TZs, respectively. In vitro, retinal axons are repelled from growing on EphA7-containing stripes. Our data support the idea that EphA7 is involved in suppressing branching anterior to future TZs. These findings suggest that opposing ephrin-A and EphA gradients are required for the proper development of the retinocollicular projection.
Tahira Rashid; A Louise Upton; Aida Blentic; Thomas Ciossek; Bernd Knöll; Ian D Thompson; Uwe Drescher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuron     Volume:  47     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-05     Completed Date:  2005-09-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  57-69     Citation Subset:  IM    
MRC Centre for Developmental Neurobiology, King's College London, New Hunt's House, Guy's Hospital Campus, London SE1 1UL, United Kingdom.
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MeSH Terms
Axons / physiology
Brain Mapping*
Ephrins / metabolism*
In Situ Hybridization
Mice, Knockout
RNA / biosynthesis,  genetics
Receptor, EphA7 / metabolism*
Retina / cytology
Superior Colliculi / metabolism*,  physiology*
Vision, Ocular / physiology*
Visual Pathways / physiology*
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Ephrins; 63231-63-0/RNA; EC, EphA7

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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