Document Detail


Opposing effects of intra-nucleus accumbens mu and kappa opioid agonists on sensory specific satiety.
MedLine Citation:
PMID:  17445988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mu opioid (MOP) agonists acting in the nucleus accumbens (NAcc) robustly enhance consumption of palatable foods. In addition, the effect on consumption of palatable foods produced by MOP agonists acting in the NAcc depends on both recent flavor exposure and the availability of a choice between different-flavored foods. In contrast, kappa opioid (KOP) agonists have variable effects on feeding and KOP agonists have MOP opposing behavioral actions when microinjected at several brain sites. We previously demonstrated that NAcc MOP agonists reverse the devaluation (satiety) effect of pre-feeding for a given flavor; in fact, NAcc MOP agonists selectively increase consumption of a recently sampled food. In contrast, in the present study, we found that the selective KOP agonist U50488 injected into the NAcc of rats reduced consumption of a recently sampled flavor while increasing consumption of the flavor that was not pre-fed. Intra-NAcc U50488 did not affect overall consumption or flavor preference in the absence of pre-feeding. The present data, in conjunction with our previous findings, highlight the robust and opposing role of NAcc MOP and KOP opioid receptors in palatability-based food choice and consumption and raise the possibility that an endogenous KOP agonist acting in the NAcc contributes to the phenomenon of sensory specific satiety.
Authors:
J D Woolley; B S Lee; B Kim; H L Fields
Related Documents :
23891758 - An investigational report into the causes of pine mouth events in us consumers.
11682148 - Intracerebroventricular injection of neuropeptide ff, an opioid modulating neuropeptide...
13679228 - Activation of the immune system in rats with lipopolysaccharide reduces voluntary sucro...
10852228 - Central infusion of interleukin-1 receptor antagonist fails to alter feeding and weight...
18085918 - Transfer of self-control in black (eulemur macaco) and brown (eulemur fulvus) lemurs: c...
8879418 - Reinforcing value of food in obese and non-obese women.
Publication Detail:
Type:  Journal Article     Date:  2007-04-19
Journal Detail:
Title:  Neuroscience     Volume:  146     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-28     Completed Date:  2007-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1445-52     Citation Subset:  IM    
Affiliation:
The Ernest Gallo Clinic and Research Center and the Wheeler Center for the Neurobiology of Addiction, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA. jwoolley@memory.ucsf.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analgesics / pharmacology*
Analysis of Variance
Animals
Behavior, Animal
Food Preferences / drug effects
Male
Nucleus Accumbens / drug effects*
Rats
Rats, Long-Evans
Receptors, Opioid, kappa / agonists*,  physiology
Receptors, Opioid, mu / agonists*,  physiology
Satiety Response / drug effects*
Taste
Time Factors
Chemical
Reg. No./Substance:
0/Analgesics; 0/Receptors, Opioid, kappa; 0/Receptors, Opioid, mu

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Heterogeneity of glutamatergic and GABAergic release machinery in cerebral cortex.
Next Document:  Influence of peripheral nerve injury on response properties of locus coeruleus neurons and coeruleos...