Document Detail

Opposing effects of intra-nucleus accumbens mu and kappa opioid agonists on sensory specific satiety.
MedLine Citation:
PMID:  17445988     Owner:  NLM     Status:  MEDLINE    
Mu opioid (MOP) agonists acting in the nucleus accumbens (NAcc) robustly enhance consumption of palatable foods. In addition, the effect on consumption of palatable foods produced by MOP agonists acting in the NAcc depends on both recent flavor exposure and the availability of a choice between different-flavored foods. In contrast, kappa opioid (KOP) agonists have variable effects on feeding and KOP agonists have MOP opposing behavioral actions when microinjected at several brain sites. We previously demonstrated that NAcc MOP agonists reverse the devaluation (satiety) effect of pre-feeding for a given flavor; in fact, NAcc MOP agonists selectively increase consumption of a recently sampled food. In contrast, in the present study, we found that the selective KOP agonist U50488 injected into the NAcc of rats reduced consumption of a recently sampled flavor while increasing consumption of the flavor that was not pre-fed. Intra-NAcc U50488 did not affect overall consumption or flavor preference in the absence of pre-feeding. The present data, in conjunction with our previous findings, highlight the robust and opposing role of NAcc MOP and KOP opioid receptors in palatability-based food choice and consumption and raise the possibility that an endogenous KOP agonist acting in the NAcc contributes to the phenomenon of sensory specific satiety.
J D Woolley; B S Lee; B Kim; H L Fields
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Publication Detail:
Type:  Journal Article     Date:  2007-04-19
Journal Detail:
Title:  Neuroscience     Volume:  146     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-28     Completed Date:  2007-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1445-52     Citation Subset:  IM    
The Ernest Gallo Clinic and Research Center and the Wheeler Center for the Neurobiology of Addiction, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
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MeSH Terms
Analgesics / pharmacology*
Analysis of Variance
Behavior, Animal
Food Preferences / drug effects
Nucleus Accumbens / drug effects*
Rats, Long-Evans
Receptors, Opioid, kappa / agonists*,  physiology
Receptors, Opioid, mu / agonists*,  physiology
Satiety Response / drug effects*
Time Factors
Reg. No./Substance:
0/Analgesics; 0/Receptors, Opioid, kappa; 0/Receptors, Opioid, mu

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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