| Opposing effects of dietary sugar and saturated fat on cardiovascular risk factors and glucose metabolism in mitochondrially impaired mice. | |
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MedLine Citation:
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PMID: 20221766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Both dietary fat and dietary sucrose are major components of Western diets that may differentially affect the risk for body mass gain, diabetes mellitus, and cardiovascular disease. METHODS: We have phenotypically analyzed mice with ubiquitously impaired expression of mitochondrial frataxin protein that were challenged with diets differing in macronutrient content, namely high-sucrose/low-fat and high-saturated fat/low-sugar diets. RESULTS: We find here that a high-sucrose/low-fat diet has especially detrimental effects in mice with impaired mitochondrial metabolism promoting several independent cardiovascular risk factors, including impaired glucose metabolism, fasting hyperinsulinemia, reduced glucose-stimulated insulin secretion, increased serum triglycerides, and elevated cholesterol levels due to increased expression of HMG-CoA reductase. In contrast, a high-saturated fat/low-sugar diet protects mice with impaired mitochondrial metabolism from diet-induced obesity by increasing total energy expenditure and increasing expression of ACAA2, a rate-limiting enzyme of mitochondrial beta-oxidation, whereas no concomitant improvement of glucose metabolism was observed. CONCLUSIONS: Taken together, our results suggest that mitochondrial dysfunction may cause sucrose to become a multifunctional cardiovascular risk factor, whereas low-sugar diets high in saturated fat may prevent weight gain without improving glucose metabolism. |
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Authors:
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Doreen Kuhlow; Kim Zarse; Anja Voigt; Tim J Schulz; Klaus J Petzke; Lutz Schomburg; Andreas F H Pfeiffer; Michael Ristow |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-10 |
Journal Detail:
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Title: European journal of nutrition Volume: 49 ISSN: 1436-6215 ISO Abbreviation: Eur J Nutr Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-24 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888704 Medline TA: Eur J Nutr Country: Germany |
Other Details:
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Languages: eng Pagination: 417-27 Citation Subset: IM |
Affiliation:
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Department of Human Nutrition, Institute of Nutrition, University of Jena, 07743 Jena, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiovascular Diseases / diet therapy* Cardiovascular System / metabolism Cholesterol / blood, metabolism Diabetes Mellitus / diet therapy Diet, Fat-Restricted Dietary Fats / blood*, metabolism Dietary Sucrose / blood*, metabolism Gene Knockdown Techniques Glucose / metabolism* Insulin / secretion Iron-Binding Proteins / metabolism Male Mice Mitochondria / metabolism* Obesity / diet therapy Oxidation-Reduction Risk Factors Triglycerides / blood, metabolism Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Dietary Sucrose; 0/Iron-Binding Proteins; 0/Triglycerides; 0/frataxin; 11061-68-0/Insulin; 50-99-7/Glucose; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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