| Opposing effects of NaCl restriction and carbohydrate loading on urine volume in diabetic rats. | |
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MedLine Citation:
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PMID: 21281457 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: To test the effects of dietary NaCl and carbohydrate content on urine volume in diabetic rats. Methods: Streptozotocin-induced diabetic rats were subjected to NaCl-restriction using either a NaCl-deficient carbohydrate-rich synthetic diet (Altromin C1036) supplemented to contain 0.16% NaCl (C1036+lowNaCl) or a modified normal cereal based diet (Altromin 1320) containing 0.086 NaCl (lowNaCl-1320). Normal diet contained 0.2683% NaCl. Results: Using the C1036+lowNaCl diet, earlier reported paradoxical increases in water intake and urine volume of diabetic rats were reproduced. However, water intake and urine volume also increased in diabetic rats offered the synthetic C1036 diet supplemented with NaCl to normal levels. Using the lowNaCl-1320 diet, water intake and urine volume were markedly reduced. Highly significant correlations between urine volume and both osmotic output and urinary glucose excretion were found in diabetic rats on normal diet, but these correlations were absent in diabetic rats on synthetic diet, which showed higher urine volumes than expected from the correlations. In contrast, urine volume was significantly correlated with carbohydrate intake in diabetic rats, irrespective of the diet. Conclusions: 1) The synthetic diet dramatically increases the urine volume in STZ-DM rats irrespectively of NaCl-content. 2) Rats with STZ-DM on a normal diet show reduced water intake and urine volume in response to dietary NaCl restriction. 3) A shift to high carbohydrate diet induces polyuria in STZ-DM rats. 4) Urine volume in all STZ-DM rats only shows correlation with with dietary carbohydrate intake. 5) Glucose-driven osmotic diuresis is unlike to explain the carbohydrate-induced polyuria. |
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Authors:
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Heidi A O'Neill; Tae-Hwan Kwon; Troels Ring; Henrik Dimke; Janne Lebeck; Jørgen Frøkiaer; Patrick B Collins; Søren Nielsen; Sebastian Frische |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-1 |
Journal Detail:
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Title: Acta physiologica (Oxford, England) Volume: - ISSN: 1748-1716 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262545 Medline TA: Acta Physiol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Scandinavian Physiological Society. |
Affiliation:
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The Water and Salt Research Center, University of Aarhus, DK-8000 Aarhus C, Denmark Department of Biochemistry, RCSI, Dublin, Ireland Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Taegu 700-422, Korea Department of Nephrology, Aalborg Hospital, DK-9000, Aalborg, Denmark Institute of Clinical Medicine, Aarhus University Hospital, DK-8200 Aarhus N, Denmark Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark. |
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