Document Detail

Opposing effects of 5,7-DHT infusions into the orbitofrontal cortex and amygdala on flexible responding.
MedLine Citation:
PMID:  19903764     Owner:  NLM     Status:  MEDLINE    
Central serotonin is implicated in a variety of emotional and behavioral control processes. Serotonin depletion can lead to exaggerated aversive processing and deficient response inhibition, effects that have been linked to serotonin's actions in the amygdala and orbitofrontal cortex (OFC), respectively. However, a direct comparison of serotonin manipulations within the OFC and amygdala in the same experimental context has not been undertaken. This study compared the effects of infusing the serotonin neurotoxin, 5,7-dihydroxytryptamine into the OFC and amygdala of marmosets performing an appetitive test of response inhibition. Marmosets had to learn to inhibit a prepotent response tendency to choose a box containing high-incentive food and instead choose a box containing low-incentive food, to obtain reward. OFC infusions caused long-lasting reductions in serotonin tissue levels, as revealed at postmortem, and exaggerated prepotent responses. In contrast, the significantly reduced prepotent responses following amygdala infusions occurred at a time when serotonin tissue levels had undergone considerable recovery, but there remained residual reductions in extracellular serotonin, in vivo. These opposing behavioral effects of serotonin manipulations in the same experimental context may be understood in terms of the top-down regulatory control of the amygdala by the OFC.
M S Man; J W Dalley; A C Roberts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-10
Journal Detail:
Title:  Cerebral cortex (New York, N.Y. : 1991)     Volume:  20     ISSN:  1460-2199     ISO Abbreviation:  Cereb. Cortex     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110718     Medline TA:  Cereb Cortex     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1668-75     Citation Subset:  IM    
Department of Physiology, University of Cambridge, Cambridge CB2 3DY, UK.
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MeSH Terms
5,7-Dihydroxytryptamine / pharmacology*
Amygdala / cytology,  drug effects*,  injuries,  physiology
Analysis of Variance
Choice Behavior / drug effects
Conditioning, Operant / drug effects
Discrimination Learning / drug effects*
Extracellular Fluid / drug effects,  metabolism
Food Preferences / drug effects
Hydroxyindoleacetic Acid / metabolism
Inhibition (Psychology)*
Microdialysis / methods
Prefrontal Cortex / cytology,  drug effects*,  injuries,  physiology
Serotonin / metabolism
Serotonin Agents / pharmacology*
Grant Support
G0401411//Medical Research Council; //Wellcome Trust
Reg. No./Substance:
0/Serotonin Agents; 31363-74-3/5,7-Dihydroxytryptamine; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid

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