| Opposing effects of 5,7-DHT infusions into the orbitofrontal cortex and amygdala on flexible responding. | |
MedLine Citation:
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PMID: 19903764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Central serotonin is implicated in a variety of emotional and behavioral control processes. Serotonin depletion can lead to exaggerated aversive processing and deficient response inhibition, effects that have been linked to serotonin's actions in the amygdala and orbitofrontal cortex (OFC), respectively. However, a direct comparison of serotonin manipulations within the OFC and amygdala in the same experimental context has not been undertaken. This study compared the effects of infusing the serotonin neurotoxin, 5,7-dihydroxytryptamine into the OFC and amygdala of marmosets performing an appetitive test of response inhibition. Marmosets had to learn to inhibit a prepotent response tendency to choose a box containing high-incentive food and instead choose a box containing low-incentive food, to obtain reward. OFC infusions caused long-lasting reductions in serotonin tissue levels, as revealed at postmortem, and exaggerated prepotent responses. In contrast, the significantly reduced prepotent responses following amygdala infusions occurred at a time when serotonin tissue levels had undergone considerable recovery, but there remained residual reductions in extracellular serotonin, in vivo. These opposing behavioral effects of serotonin manipulations in the same experimental context may be understood in terms of the top-down regulatory control of the amygdala by the OFC. |
Authors:
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M S Man; J W Dalley; A C Roberts |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-10 |
Journal Detail:
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Title: Cerebral cortex (New York, N.Y. : 1991) Volume: 20 ISSN: 1460-2199 ISO Abbreviation: Cereb. Cortex Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-08-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9110718 Medline TA: Cereb Cortex Country: United States |
Other Details:
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Languages: eng Pagination: 1668-75 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Cambridge, Cambridge CB2 3DY, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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5,7-Dihydroxytryptamine
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pharmacology* Amygdala / cytology, drug effects*, injuries, physiology Analysis of Variance Animals Callithrix Choice Behavior / drug effects Conditioning, Operant / drug effects Discrimination Learning / drug effects* Extracellular Fluid / drug effects, metabolism Female Food Preferences / drug effects Hydroxyindoleacetic Acid / metabolism Inhibition (Psychology)* Male Microdialysis / methods Prefrontal Cortex / cytology, drug effects*, injuries, physiology Serotonin / metabolism Serotonin Agents / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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G0401411//Medical Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Agents; 31363-74-3/5,7-Dihydroxytryptamine; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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