Document Detail


Opportunities in abdominal aortic aneurysm research: epidemiology, genetics, and pathophysiology.
MedLine Citation:
PMID:  22794334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aortic aneurysms are a complex genetic disorder with known environmental risk factors such as smoking. Along the length of the aorta, significant heterogeneity occurs in the distribution of aneurysmal disease. The prevalence of aneurysm in the abdominal aorta is at least nine times higher than that in the thoracic section of the aorta. A number of studies have shown that aortic aneurysms are frequently familial, even when they are not associated with rare heritable disorders such as Marfan syndrome or Ehlers-Danlos syndrome type IV. The pathobiology of aortic aneurysms is complex and largely unsolved. Unbiased whole-genome approaches are now being used to elucidate the genetic basis of aortic aneurysms to uncover the germline genetic variants that influence the disease risk. The findings will provide critical information about underlying biology of the disease and will help identify potential targets for pharmacological therapies. These studies may lead to therapies that may increase survival rates for individuals with aortic aneurysms and reduce the need for surgical interventions. Abdominal aortic aneurysms were the topic of an international conference "Abdominal Aortic Aneurysm: Epidemiology, Genetics, and Pathophysiology" held recently at the Geisinger Clinic, Danville, Pennsylvania.
Authors:
Helena Kuivaniemi; James R Elmore
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of vascular surgery     Volume:  26     ISSN:  1615-5947     ISO Abbreviation:  Ann Vasc Surg     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-16     Completed Date:  2012-11-30     Revised Date:  2013-06-19    
Medline Journal Info:
Nlm Unique ID:  8703941     Medline TA:  Ann Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  862-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Annals of Vascular Surgery Inc. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Vascular and Endovascular Surgery, The Sigfried and Janet Weis Center for Research, Geisinger Clinic, Danville, PA 17822-2610, USA. shkuivaniemi@geisinger.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Aortic Aneurysm, Abdominal* / diagnosis,  epidemiology,  genetics,  physiopathology,  therapy
Aortic Rupture* / diagnosis,  epidemiology,  genetics,  physiopathology,  therapy
Biomedical Research*
Congresses as Topic
Disease Models, Animal
Environment
Genetic Markers
Genetic Predisposition to Disease
Heredity
Humans
Mass Screening / methods
Pedigree
Prognosis
Risk Assessment
Risk Factors
Grant Support
ID/Acronym/Agency:
R01 HL064310/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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