Document Detail


Opportunistic infections of the central nervous system in the transplant patient.
MedLine Citation:
PMID:  23881624     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Therapeutic advances in transplantation medicine have resulted in ever expanding patient populations that receive organ or stem cell transplantation. Modern potent immunomodulatory therapies have resulted in improvements in allograft and patient survival, but, consequently, as a result of the immunosuppressive state, transplant recipients are highly vulnerable to infection, including those that affect the central nervous system (CNS). CNS infections present a diagnostic and therapeutic challenge for clinicians involved in the care of the transplant patient, with a propensity to result in profound morbidity and often high mortality in this patient population. Here, we review major opportunistic pathogens of the CNS seen in transplant patients, highlighting distinguishing epidemiologic and clinical features.
Authors:
Bruce A Cohen; Valentina Stosor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  13     ISSN:  1534-6293     ISO Abbreviation:  Curr Neurol Neurosci Rep     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-07-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  376     Citation Subset:  IM    
Affiliation:
Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, 710 North Lake Shore Drive, Abbott Hall 1121, Chicago, IL, 60611, USA, bac106@northwestern.edu.
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