| Opponent interactions between serotonin and dopamine. | |
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MedLine Citation:
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PMID: 12371515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anatomical and pharmacological evidence suggests that the dorsal raphe serotonin system and the ventral tegmental and substantia nigra dopamine system may act as mutual opponents. In the light of the temporal difference model of the involvement of the dopamine system in reward learning, we consider three aspects of motivational opponency involving dopamine and serotonin. We suggest that a tonic serotonergic signal reports the long-run average reward rate as part of an average-case reinforcement learning model; that a tonic dopaminergic signal reports the long-run average punishment rate in a similar context; and finally speculate that a phasic serotonin signal might report an ongoing prediction error for future punishment. |
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Authors:
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Nathaniel D Daw; Sham Kakade; Peter Dayan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Neural networks : the official journal of the International Neural Network Society Volume: 15 ISSN: 0893-6080 ISO Abbreviation: Neural Netw Publication Date: 2002 Jun-Jul |
Date Detail:
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Created Date: 2002-10-09 Completed Date: 2003-02-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8805018 Medline TA: Neural Netw Country: United States |
Other Details:
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Languages: eng Pagination: 603-16 Citation Subset: IM |
Affiliation:
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Computer Science Department and Center for the Neural Basis of Cognition, School of Computer Science, Carnegie Mellon University, Pittsburgh PA 15213-3891, USA. daw@cs.cmu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Conditioning (Psychology) / physiology* Dopamine / physiology* Humans Learning / physiology Reward* Serotonin / physiology* |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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