Document Detail

Opponent interactions between serotonin and dopamine.
MedLine Citation:
PMID:  12371515     Owner:  NLM     Status:  MEDLINE    
Anatomical and pharmacological evidence suggests that the dorsal raphe serotonin system and the ventral tegmental and substantia nigra dopamine system may act as mutual opponents. In the light of the temporal difference model of the involvement of the dopamine system in reward learning, we consider three aspects of motivational opponency involving dopamine and serotonin. We suggest that a tonic serotonergic signal reports the long-run average reward rate as part of an average-case reinforcement learning model; that a tonic dopaminergic signal reports the long-run average punishment rate in a similar context; and finally speculate that a phasic serotonin signal might report an ongoing prediction error for future punishment.
Nathaniel D Daw; Sham Kakade; Peter Dayan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Neural networks : the official journal of the International Neural Network Society     Volume:  15     ISSN:  0893-6080     ISO Abbreviation:  Neural Netw     Publication Date:    2002 Jun-Jul
Date Detail:
Created Date:  2002-10-09     Completed Date:  2003-02-11     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8805018     Medline TA:  Neural Netw     Country:  United States    
Other Details:
Languages:  eng     Pagination:  603-16     Citation Subset:  IM    
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MeSH Terms
Conditioning (Psychology) / physiology*
Dopamine / physiology*
Learning / physiology
Serotonin / physiology*
Reg. No./Substance:
333DO1RDJY/Serotonin; VTD58H1Z2X/Dopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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