| Opium Consumption and Coronary Atherosclerosis in Diabetic Patients: A Propensity Score-Matched Study. | |
| | |
MedLine Citation:
|
PMID: 21800277 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
There is a traditional belief among Eastern people that opium may have ameliorating effects on cardiovascular risk factors, especially diabetes; thus, it is widely used among diabetic patients. We attempted to investigate the association of opium consumption with coronary artery disease (CAD) in diabetic patients. A cross-sectional study was conducted on diabetic patients undergoing coronary angiography in our center. Out of 1925 diabetic patients included in the study, 228 were opium users, and the remaining 1697 non-opium users were used as a pool of potential comparators. Propensity scores were used to match the 228 opium consumers with 228 matched comparators for age, sex, and smoking status. The Gensini score and extent score were respectively used to assess the angiographic severity and extent of CAD. The mean Gensini score (86.9 ± 62.7 vs. 59.6 ± 43.4, p < 0.0001) and extent score (7.1 ± 2.9 vs. 5.9 ± 2.9, p < 0.0001) were significantly higher in opium user diabetic patients than in non-opium users. After adjustment for potential confounders, a dose-response relationship was observed between dose of opium and the Gensini score ( β = 0.27, p = 0.04). There were no significant differences between the routes of opium administration (inhalation vs. oral) regarding the severity and extent of CAD. In conclusion, exposure to opium in diabetic patients may be positively associated with the risk of CAD, and with the angiographically determined severity and extent of the disease. Furthermore, dosage of opium consumption may correlate with severity of CAD. |
| | |
Authors:
|
Seyed Kianoosh Hosseini; Farzad Masoudkabir; Ali Vasheghani-Farahani; Saeed Alipour-Parsa; Mahmood Sheikh Fathollahi; Abbas Rahimi-Foroushani; Elham Hakki; Hamidreza Goodarzynejad; Hassan Eftekhar |
Related Documents
:
|
20371457 - Ppargamma activation: a potential treatment for pulmonary hypertension. 21499837 - Transdermal insulin delivery using microdermabrasion. 8529517 - Niddm--the devastating disease. 20207607 - Weight gain and insulin resistance in children treated with valproate: the influence of... 15140637 - Antidiabetic and hypolipidemic potential of drf 2519--a dual activator of ppar-alpha an... 11483507 - Ergosterol is required for the sec18/atp-dependent priming step of homotypic vacuole fu... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-28 |
Journal Detail:
|
Title: Planta medica Volume: - ISSN: 1439-0221 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0066751 Medline TA: Planta Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
|
Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cytotoxicity and Mode of Action of Four Naturally Occuring Flavonoids from the Genus Dorstenia: Ganc...
Next Document: Structure/Antileishmanial Activity Relationship Study of Naphthoquinones and Dependency of the Mode ...