Document Detail

Opioids and the skin--where do we stand?
MedLine Citation:
PMID:  19382313     Owner:  NLM     Status:  MEDLINE    
The common ectodermal origin of the skin and nervous systems can be expected to predict likely interactions in the adult. Over the last couple of decades much progress has been made to elucidate the nature of these interactions, which provide multidirectional controls between the centrally located brain and the peripherally located skin and immune system. The opioid system is an excellent example of such an interaction and there is growing evidence that opioid receptors (OR) and their endogenous opioid agonists are functional in different skin structures, including peripheral nerve fibres, keratinocytes, melanocytes, hair follicles and immune cells. Greater knowledge of these skin-associated opioid interactions will be important for the treatment of chronic and acute pain and pruritus. Topical treatment of the skin with opioid ligands is particularly attractive as they are active with few side effects, especially if they cannot cross the blood-brain barrier. Moreover, cutaneous activation of the opioid system (e.g. by peripheral nerves, cutaneous and immune cells, especially in inflamed and damaged skin) can influence cell differentiation and apoptosis, and thus may be important for the repair of damaged skin. While many of the pieces of this intriguing puzzle remain to be found, we attempt in this review to weave a thread around available data to discuss how the peripheral opioid system may impact on different key players in skin physiology and pathology.
Paul L Bigliardi; Desmond J Tobin; Claire Gaveriaux-Ruff; Mei Bigliardi-Qi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental dermatology     Volume:  18     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-20     Completed Date:  2009-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  424-30     Citation Subset:  IM    
Department of Dermatology, Neurodermatology Research, CHUV, University of Lausanne, Lausanne, Switzerland.
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MeSH Terms
Analgesics, Opioid / metabolism*
Cell Differentiation
Gene Expression Regulation
Immune System
Melanocytes / metabolism
Pruritus / metabolism
RNA, Messenger / metabolism
Receptors, Opioid / immunology,  physiology
Skin / embryology,  metabolism*
Skin Physiological Phenomena*
Reg. No./Substance:
0/Analgesics, Opioid; 0/Ligands; 0/RNA, Messenger; 0/Receptors, Opioid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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