| Opioids, opioid receptors, and the immune response. | |
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MedLine Citation:
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PMID: 11245967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is now clear that opioid receptors participate in the function of the cells of the immune system, and evidence suggests that opioids modulate both innate and acquired immune responses. We review literature here which establishes that mu-, kappa-, and delta-opioid compounds alter resistance to a variety of infectious agents, including the Human Immunodeficiency Virus (HIV). The nature of the immunomodulatory activity of the opioids has been the subject of a great deal of research over the last ten years. There is increasing evidence that effects of opioids on the immune response are mediated at several levels. Modulation of the inflammatory response appears to be a target of these compounds, including effects on phagocytic activity, as well as the response of cells to various chemoattractant molecules. Moreover, findings from several laboratories have demonstrated the impact of opioid treatment on antibody responses, and the molecular basis for this effect is likely due, at least in part, to the modulation of both cytokine and cytokine receptor expression. Future research should provide a clearer understanding of the cellular and molecular targets of opioid action within the immune system. |
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Authors:
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L McCarthy; M Wetzel; J K Sliker; T K Eisenstein; T J Rogers |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Drug and alcohol dependence Volume: 62 ISSN: 0376-8716 ISO Abbreviation: Drug Alcohol Depend Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-03-14 Completed Date: 2001-08-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7513587 Medline TA: Drug Alcohol Depend Country: Ireland |
Other Details:
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Languages: eng Pagination: 111-23 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, Temple University School of Medicine, 3400 N. Broad Street, Philadelphia, PA 19140, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Viral
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drug effects Apoptosis / drug effects HIV Seropositivity / immunology Hematopoiesis / drug effects Humans Immune System / drug effects, immunology Leukocytes, Mononuclear / immunology Morphine / adverse effects Narcotics / adverse effects, immunology*, metabolism Neuroimmunomodulation / drug effects, immunology Opioid-Related Disorders / immunology RNA, Messenger / immunology Receptors, Opioid / immunology*, metabolism Reverse Transcriptase Polymerase Chain Reaction |
| Grant Support | |
ID/Acronym/Agency:
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DA 06650/DA/NIDA NIH HHS; DA 11130/DA/NIDA NIH HHS; DA 11134/DA/NIDA NIH HHS; F31 DA 05894/DA/NIDA NIH HHS; T32 DA07237/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Narcotics; 0/RNA, Messenger; 0/Receptors, Opioid; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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