Document Detail


Opioids and food intake: distributed functional neural pathways?
MedLine Citation:
PMID:  10657513     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Agonists of the mu, delta, kappa and ORL(1)opioid receptors increase food intake while opioid receptor blockade decreases food intake. The majority of the collected data related to opioids and feeding has led to the speculation that opioids are involved in meal maintenance and orosensory reward; however, some data suggest that opioids may impact feeding associated with energy needs. Based on the wide distribution of CNS opioid receptors and the presence of other neuropeptides in the vicinity of opioidergic pathways, it seems likely that opioids affect multiple feeding systems. For example, opioids in the hindbrain might be involved in both sensory and metabolic aspects of food intake, those in the amygdala in processing of 'emotional' properties of foods, and those in the hypothalamus in energy needs. In this review we present data which support functional diversity of opioids in feeding behavior.
Authors:
M J Glass; C J Billington; A S Levine
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Neuropeptides     Volume:  33     ISSN:  0143-4179     ISO Abbreviation:  Neuropeptides     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-06-02     Completed Date:  2000-06-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  360-8     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Harcourt Publishers Ltd.
Affiliation:
Department of Veterans Affairs Medical Center, Minnesota Obesity Center, University of Minnesota, Minneapolis, MN, 55455, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Eating / physiology*
Humans
Neural Pathways / physiology*
Opioid Peptides / physiology*
Receptors, Opioid / physiology*
Grant Support
ID/Acronym/Agency:
DA-03999/DA/NIDA NIH HHS; DK-42698/DK/NIDDK NIH HHS; TA-DA-07097/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Opioid Peptides; 0/Receptors, Opioid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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