Document Detail


Opioids as facilitators of feeding: can any food be rewarding?
MedLine Citation:
PMID:  21536057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Palatability is one of the most rewarding aspects of consummatory behavior. Opioids, potent facilitators of intake of sweet and fat tastants, are thought to mediate hedonics of feeding. However, the rewarding context of consumption is not limited to palatability, and gratification can be achieved through other means, e.g., eating to satisfy hunger. The current review discusses the role of opioid peptides in food intake regulation by incorporating this expanded concept of feeding reward. We present evidence that, aside from increasing sugar/fat consumption, opioids propel the intake of diets whose gustatory value is low but are nonetheless consumed under circumstances allowing feeding gratification to occur. Opioids enhance reward-driven consumption by acting within the classical reward circuitry and also by signaling reward at sites that regulate other aspects of food intake, such as satiety and aversion. We conclude that, due to the complexity of neural and functional interactions, opioids are capable of enhancing pleasure of eating any food--palatable, bland or even aversive--making any meal into a more rewarding experience, despite possible consequences.
Authors:
Pawel K Olszewski; Johan Alsiö; Helgi B Schiöth; Allen S Levine
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-04-28
Journal Detail:
Title:  Physiology & behavior     Volume:  104     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-03     Completed Date:  2011-10-14     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-10     Citation Subset:  IM    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / physiology*
Eating / physiology*
Feeding Behavior / physiology*
Opioid Peptides / metabolism*
Reward*
Chemical
Reg. No./Substance:
0/Opioid Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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