| Opioids and the Immune System: What is their Mechanism of Action? | |
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MedLine Citation:
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PMID: 21627636 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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There is a significant literature showing that morphine and other opioids modulate immune responses. The literature supports many mechanisms by which this may occur. In vitro experiments provide evidence for direct actions of opioids on immune cells using a variety of functional end-points. When these drugs are given in vivo, a plethora of immune parameters are also altered. The paper in this issue of the journal by Zhang et al provides new information on morphine alteration of immune cell subsets in the spleen and thymus of mice and the potential role of glucocorticoids in these observed phenomena. This Commentary reviews the in vitro activities of morphine on leukocytes, as well as other documented mechanisms by which morphine can alter immune function in vivo. |
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Authors:
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Toby K Eisenstein |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-31 |
Journal Detail:
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Title: British journal of pharmacology Volume: - ISSN: 1476-5381 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-6-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Author. British Journal of Pharmacology © 2011 The British Pharmacological Society. |
Affiliation:
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Department of Microbiology and Immunology and Center for Substance Abuse Research. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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