| Opioidergic modulation of cocaine conditioned place preferences. | |
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MedLine Citation:
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PMID: 1552818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies have begun to assess the utility of opioid agonists and antagonists for the treatment of cocaine addiction. The present studies assess the effects of naltrexone or methadone on cocaine's reinforcing properties using the conditioned place preference (CPP) test. The results indicate that a 56 mg/kg dose of naltrexone, given 4 hr prior to conditioning, attenuates cocaine's CPP. In contrast, methadone (8 mg/kg), given 1 hr prior to conditioning, enhanced cocaine's reinforcing properties. These results support the suggestion that opioid antagonists may have clinical utility in treating cocaine addiction. The results with methadone lead to a possible explanation for the higher rates of cocaine use in methadone-treated heroin addicts. |
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Authors:
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E J Bilsky; M J Montegut; C L Delong; L D Reid |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Life sciences Volume: 50 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-04-28 Completed Date: 1992-04-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: PL85-90 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Arizona, Tucson 85724. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Cocaine / pharmacology* Conditioning (Psychology) / drug effects* Male Methadone / pharmacology* Naltrexone / pharmacology* Rats Rats, Inbred Strains Reference Values Reinforcement (Psychology) |
| Grant Support | |
ID/Acronym/Agency:
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DA 04440/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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16590-41-3/Naltrexone; 50-36-2/Cocaine; 76-99-3/Methadone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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