Document Detail


Opioid withdrawal in neonates after continuous infusions of morphine or fentanyl during extracorporeal membrane oxygenation.
MedLine Citation:
PMID:  9740886     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Complications of opioid analgesia include tolerance and withdrawal. OBJECTIVES: To determine the effects of morphine and fentanyl on the prevalence of withdrawal after extracorporeal membrane oxygenation. METHODS: Two groups of neonates were compared during and after extracorporeal membrane oxygenation: a prospective group receiving a continuous infusion of morphine for analgesia and sedation and a retrospective group who had received a continuous infusion of fentanyl. RESULTS: Neonates receiving morphine required significantly less supplemental analgesia (P < .001) than did neonates who had received fentanyl and had a significantly lower prevalence of withdrawal after the therapy (P = .01). Neonates receiving morphine were discharged from the hospital a mean of 9.6 days sooner (P = .01) than neonates who had received fentanyl. CONCLUSIONS: Morphine may offer marked advantages over fentanyl for providing continuous analgesia and sedation in neonates.
Authors:
L S Franck; J Vilardi; D Durand; R Powers
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of critical care : an official publication, American Association of Critical-Care Nurses     Volume:  7     ISSN:  1062-3264     ISO Abbreviation:  Am. J. Crit. Care     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-11-12     Completed Date:  1998-11-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9211547     Medline TA:  Am J Crit Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  364-9     Citation Subset:  IM; N    
Affiliation:
School of Nursing, University of California, San Francisco, USA.
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MeSH Terms
Descriptor/Qualifier:
Analgesics, Opioid / adverse effects*
Extracorporeal Membrane Oxygenation*
Fentanyl / adverse effects*
Humans
Infant, Newborn
Infusions, Intravenous
Morphine / adverse effects*
Nursing Assessment
Nursing Records
Patient Care Planning
Prevalence
Prospective Studies
Retrospective Studies
Substance Withdrawal Syndrome / etiology*,  nursing
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 437-38-7/Fentanyl; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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