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Opioid μ-receptors in the rostral medullary raphe modulate hypoxia-induced hyperpnea in unanesthetized rats.
MedLine Citation:
PMID:  21827637     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim:  It has been suggested that the medullary raphe (MR) plays a key role in the physiological responses to hypoxia. As opioid μ-receptors have been found in the MR, we studied the putative role of opioid μ-receptors in the rostral MR (rMR) region on ventilation in normal and 7% hypoxic conditions. Methods:  We measured pulmonary ventilation () and the body temperatures (Tb) of male Wistar rats before and after the selective opioid μ-receptor antagonist CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2, cyclic, 0.1 μg/0.1 μL) was microinjected into the rMR during normoxia or after 60 minutes of hypoxia. Results:  The animals treated with intra-rMR CTAP exhibited an attenuation of the ventilatory response to hypoxia (430 ± 86 mL kg(-1) min(-1) ) compared to the control group (790 ± 82 mL kg(-1) min(-1) ) (P<0.05). No differences in the Tb were observed among groups during hypoxia. Conclusion:  These data suggest that opioids acting on μ-receptors in the rMR exert an excitatory modulation of hyperventilation induced by hypoxia.
Authors:
Mirela Barros Dias; Tatiane B Nucci; Luiz G S Branco; Luciane H Gargaglioni
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-9
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  -     ISSN:  1748-1716     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Scandinavian Physiological Society.
Affiliation:
Department of Physiological Sciences, Federal University of Goias, Goiania, GO, Brazil. Department of Morphology, Stomatology and Physiology, Dental School of Ribeirao Preto, University of Sao Paulo, SP, Brazil. Department of Animal Morphology and Physiology, Sao Paulo State University-FCAV at Jaboticabal, SP, Brazil.
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