Document Detail

Opioid receptor blockade reduces maternal affect and social grooming in rhesus monkeys.
MedLine Citation:
PMID:  8391149     Owner:  NLM     Status:  MEDLINE    
Seven lactating female rhesus macaques, housed in social groups, were administered with low doses (0.5 mg/kg) of the opioid antagonist naloxone when their infants were 4, 6, 8, and 10 weeks old. A control group received saline. Mothers receiving naloxone were involved in less grooming with other group members, and were less protective towards their infants. By infant-age week 8 they also groomed their infants less, while other monkeys groomed the infants more. Other behavioural measures of mother-infant interactions were not altered. With time, from infant-age week 6 onwards, some short-lived dysphoric conditioned drug responses to naloxone became apparent, although these were not correlated with the decline in social interaction. These results are interpreted in terms of possible interference of naloxone with maternal affect.
F L Martel; C M Nevison; F D Rayment; M J Simpson; E B Keverne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  18     ISSN:  0306-4530     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  1993  
Date Detail:
Created Date:  1993-07-28     Completed Date:  1993-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  307-21     Citation Subset:  IM    
University of Cambridge, Sub-Department of Animal Behaviour, Madingley, U.K.
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MeSH Terms
Affect / drug effects*,  physiology
Animals, Newborn
Grooming / drug effects*,  physiology
Macaca mulatta
Maternal Behavior*
Naloxone / pharmacology*
Receptors, Opioid / drug effects*,  physiology
Social Behavior*
Reg. No./Substance:
0/Receptors, Opioid; 465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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