| Opioid receptor blockade reduces maternal affect and social grooming in rhesus monkeys. | |
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MedLine Citation:
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PMID: 8391149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seven lactating female rhesus macaques, housed in social groups, were administered with low doses (0.5 mg/kg) of the opioid antagonist naloxone when their infants were 4, 6, 8, and 10 weeks old. A control group received saline. Mothers receiving naloxone were involved in less grooming with other group members, and were less protective towards their infants. By infant-age week 8 they also groomed their infants less, while other monkeys groomed the infants more. Other behavioural measures of mother-infant interactions were not altered. With time, from infant-age week 6 onwards, some short-lived dysphoric conditioned drug responses to naloxone became apparent, although these were not correlated with the decline in social interaction. These results are interpreted in terms of possible interference of naloxone with maternal affect. |
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Authors:
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F L Martel; C M Nevison; F D Rayment; M J Simpson; E B Keverne |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Psychoneuroendocrinology Volume: 18 ISSN: 0306-4530 ISO Abbreviation: Psychoneuroendocrinology Publication Date: 1993 |
Date Detail:
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Created Date: 1993-07-28 Completed Date: 1993-07-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7612148 Medline TA: Psychoneuroendocrinology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 307-21 Citation Subset: IM |
Affiliation:
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University of Cambridge, Sub-Department of Animal Behaviour, Madingley, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Affect
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drug effects*,
physiology Animals Animals, Newborn Female Grooming / drug effects*, physiology Macaca mulatta Male Maternal Behavior* Motivation Naloxone / pharmacology* Receptors, Opioid / drug effects*, physiology Social Behavior* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Opioid; 465-65-6/Naloxone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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