| Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity. | |
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MedLine Citation:
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PMID: 6691146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cytotoxic activity of natural killer cells was investigated in rats subjected to one of two inescapable footshock stress paradigms, both of which induce analgesia, but only one via activation of opioid mechanisms. Splenic natural killer cell activity was suppressed by the opioid, but not the nonopioid, form of stress. This suppression was blocked by the opioid antagonist naltrexone. Similar suppression of natural killer activity was induced by high doses of morphine. These results suggest that endogenous opioid peptides mediate the suppressive effect of certain forms of stress on natural killer cell cytotoxicity. |
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Authors:
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Y Shavit; J W Lewis; G W Terman; R P Gale; J C Liebeskind |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 223 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1984 Jan |
Date Detail:
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Created Date: 1984-02-14 Completed Date: 1984-02-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 188-90 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytotoxicity, Immunologic* / drug effects Dose-Response Relationship, Drug Endorphins / physiology* Female Killer Cells, Natural / immunology* Morphine / pharmacology* Naltrexone / pharmacology Rats Rats, Inbred F344 Stress, Physiological / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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MH15795/MH/NIMH NIH HHS; NS07628/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endorphins; 16590-41-3/Naltrexone; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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