Document Detail

Opioid peptides in experimental myocardial infarction. I. The effect of naloxone.
MedLine Citation:
PMID:  3618253     Owner:  NLM     Status:  MEDLINE    
The effect of intravenous administration of the opioid antagonist naloxone in rats with acute left coronary artery ligation was studied. The results demonstrated that naloxone in a dose 2 mg/kg b. w. affords its protection on infarcted animals by two mechanisms: Reduces by 22% the incidence of early arrhythmias that occur within 15-20 minutes of acute myocardial ischaemia, and are responsible for the early (up to the 30th minutes) postligation death; Reverses the hypotension that results from the development of cardiogenic shock after 30 minutes myocardial infarction. The total mortality after naloxone treatment was significantly reduced by 22%. Naloxone does not influence significantly the size of the infarcted area but the incidence of left ventricle wall perforations was decreased by 38%. Both effects of naloxone are attributed to the antagonism of opioid receptors either directly on the myocardium or through blocking the central action of beta-endorphin. A direct effect of naloxone on the cardiac muscle action potential cannot be excluded.
A Machuganska; L Somova; G Dashev; N Zlatareva; M Vassileva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica et pharmacologica Bulgarica     Volume:  13     ISSN:  0323-9950     ISO Abbreviation:  Acta Physiol Pharmacol Bulg     Publication Date:  1987  
Date Detail:
Created Date:  1987-09-24     Completed Date:  1987-09-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7512568     Medline TA:  Acta Physiol Pharmacol Bulg     Country:  BULGARIA    
Other Details:
Languages:  eng     Pagination:  26-34     Citation Subset:  IM    
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MeSH Terms
Acid-Base Equilibrium
Arrhythmias, Cardiac / physiopathology
Coronary Vessels
Myocardial Infarction / physiopathology*
Naloxone / pharmacology*
Rats, Inbred Strains
Reg. No./Substance:

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