| Opioid peptides and the control of feeding in sheep. | |
| | |
MedLine Citation:
|
PMID: 3026855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Opioid peptides, particularly beta-endorphin, methionine- (MEK) and leucine-enkephalin, and dynorphin, are involved in the regulation of food intake in mammals. The precursor molecules of these peptides undergo differential processing in brain areas producing regional concentration differences in opioids. Intraregional concentration changes also accompany alterations in feeding states. For example, MEK concentrations decrease in the basomedial hypothalamus, amygdala, and olfactory bulb in fed sheep compared with fasted sheep. Moreover, these changes are species specific. In sheep, beta-endorphin decreases in the dorsomedial and posterior hypothalami after feeding, but in the rat it is increased in the ventromedial hypothalamus and decreased in the posterior hypothalamus. In addition, immunohistochemical localization of cell bodies shows interspecies differences in concentrations. For example, dynorphin is found predominantly in the suprachiasmatic area in sheep, but in the paraventricular nucleus in the rat. These observations indicate that regulation of food intake may be differentially controlled in these species. In sheep, kappa agonists increase food intake, whereas stimulation of delta receptors inhibits feeding. Further clarification of the receptors involved in food intake will necessitate studies with more specific agonists. |
| | |
Authors:
|
C A Baile; C L McLaughlin; F C Buonomo; T J Lauterio; L Marson; M A Della-Fera |
Related Documents
:
|
1838995 - An overview of bovine spongiform encephalopathy. 11500015 - Influence of animal manures on the biology of temperate earthworm, eisenia fetida in tr... 22372665 - New image analysis of large food particles can discriminate experimentally suppressed m... 14751225 - Anaerobic transformation of 2,4,6-tnt by bovine ruminal microbes. 2212455 - Dietary preference for sweet foods in patients with dementia. 15256615 - Modular construction of early ediacaran complex life forms. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Federation proceedings Volume: 46 ISSN: 0014-9446 ISO Abbreviation: Fed. Proc. Publication Date: 1987 Jan |
Date Detail:
|
Created Date: 1987-02-26 Completed Date: 1987-02-26 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0372771 Medline TA: Fed Proc Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 173-7 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amygdala
/
physiology Animals Endorphins / physiology* Fasting Feeding Behavior / physiology* Hypothalamus / drug effects, physiology Narcotic Antagonists / pharmacology Olfactory Bulb / physiology Rats Receptors, Opioid / classification, drug effects Receptors, Opioid, delta Receptors, Opioid, kappa Sheep / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
NS20000/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Endorphins; 0/Narcotic Antagonists; 0/Receptors, Opioid; 0/Receptors, Opioid, delta; 0/Receptors, Opioid, kappa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Slugs and snails and opiate tales: opioids and feeding behavior in invertebrates.
Next Document: Biochemical characteristics of receptors for vasoactive intestinal polypeptide in nervous, endocrine...