Document Detail

Opioid peptides and the control of feeding in sheep.
MedLine Citation:
PMID:  3026855     Owner:  NLM     Status:  MEDLINE    
Opioid peptides, particularly beta-endorphin, methionine- (MEK) and leucine-enkephalin, and dynorphin, are involved in the regulation of food intake in mammals. The precursor molecules of these peptides undergo differential processing in brain areas producing regional concentration differences in opioids. Intraregional concentration changes also accompany alterations in feeding states. For example, MEK concentrations decrease in the basomedial hypothalamus, amygdala, and olfactory bulb in fed sheep compared with fasted sheep. Moreover, these changes are species specific. In sheep, beta-endorphin decreases in the dorsomedial and posterior hypothalami after feeding, but in the rat it is increased in the ventromedial hypothalamus and decreased in the posterior hypothalamus. In addition, immunohistochemical localization of cell bodies shows interspecies differences in concentrations. For example, dynorphin is found predominantly in the suprachiasmatic area in sheep, but in the paraventricular nucleus in the rat. These observations indicate that regulation of food intake may be differentially controlled in these species. In sheep, kappa agonists increase food intake, whereas stimulation of delta receptors inhibits feeding. Further clarification of the receptors involved in food intake will necessitate studies with more specific agonists.
C A Baile; C L McLaughlin; F C Buonomo; T J Lauterio; L Marson; M A Della-Fera
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Federation proceedings     Volume:  46     ISSN:  0014-9446     ISO Abbreviation:  Fed. Proc.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-02-26     Completed Date:  1987-02-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372771     Medline TA:  Fed Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  IM    
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MeSH Terms
Amygdala / physiology
Endorphins / physiology*
Feeding Behavior / physiology*
Hypothalamus / drug effects,  physiology
Narcotic Antagonists / pharmacology
Olfactory Bulb / physiology
Receptors, Opioid / classification,  drug effects
Receptors, Opioid, delta
Receptors, Opioid, kappa
Sheep / physiology*
Grant Support
Reg. No./Substance:
0/Endorphins; 0/Narcotic Antagonists; 0/Receptors, Opioid; 0/Receptors, Opioid, delta; 0/Receptors, Opioid, kappa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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