Document Detail

Opioid peptides attenuate blood pressure increase in acute respiratory failure.
MedLine Citation:
PMID:  11311734     Owner:  NLM     Status:  MEDLINE    
Plasma opioid peptides, norepinephrine, atrial natriuretic factor (ANF) and blood pressure (BP) were assessed in 24 chronic obstructive pulmonary disease patients with acute respiratory failure. Hypoxemic-hypercapnic patients had high BP, beta-endorphin, Met-enkephalin and dynorphin B, whereas hypoxemic-normocapnic and hypoxemic-hypocapnic patients showed normal BP, high beta-endorphin, and normal Met-enkephalin and dynorphin B. Norepinephrine and ANF were high in all patients, particularly in hypoxemic-hypercapnic patients. Infusion with the opioid antagonist naloxone hydrochloride significantly increased systolic blood pressure (SBP) in hypoxemic-hypercapnic (182.0 +/- 3.2 versus 205.1 +/- 3.0 mmHg; P < 0.01), hypoxemic-normocapnic (149.3 +/- 1.8 versus 169.1 +/- 2.2 mmHg; P < 0.01) and hypoxemic-hypocapnic (147.3 +/- 1.3 versus 166.8 +/- 2.2 mmHg; P < 0.01) patients, norepinephrine in hypoxemic-hypercapnic patients (3583.2 +/- 371.8 versus 5371.3 +/- 260.0 fmol/ml; P < 0.01), and reduced ANF in hypoxemic-normocapnic (18.3 +/- 0.8 versus 11.9 +/- 1.0 fmol/ml; P < 0.05) and hypoxemic-hypocapnic (18.1 +/- 1.2 versus 12.1 +/- 2.1 fmol/ml; P < 0.05) patients. These results indicate that the endogenous opioid system attenuates SBP responses in acute respiratory failure by affecting norepinephrine or ANF release.
F Fontana; P Bernardi; L Tartuferi; S Boschi; R Di Toro; S Spampinato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peptides     Volume:  22     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-20     Completed Date:  2001-08-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  631-7     Citation Subset:  IM    
Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Ospedale S. Orsola, Via Massarenti 9, 40138, Bologna, Italy.
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MeSH Terms
Acute Disease
Atrial Natriuretic Factor / blood
Blood Pressure / drug effects*
Heart Rate / drug effects
Middle Aged
Naloxone / pharmacology
Norepinephrine / blood
Opioid Peptides / antagonists & inhibitors,  pharmacology*
Respiratory Insufficiency / physiopathology*
Reg. No./Substance:
0/Opioid Peptides; 0/Placebos; 465-65-6/Naloxone; 51-41-2/Norepinephrine; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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