| Opioid peptide modulation of circulatory response to hyperventilation in humans. | |
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MedLine Citation:
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PMID: 11035209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After hyperventilation, systolic blood pressure (SBP) significantly decreased in 10 subjects (group 1), did not change in eight (group 2) and increased in 15 (group 3). Diastolic blood pressure and heart rate increased in all groups. The decrease in SBP was associated with a decrease in plasma catecholamines and increase in beta-endorphin, whereas the increase in SBP was accompanied by an increase in catecholamine and Met-enkephalin levels. Naloxone abolished the hyperventilation-induced SBP and catecholamine decrease only in group 1. These findings show an activation of the endogenous opioid system after hyperventilation and the role of beta-endorphin in reducing SBP in response to the test. |
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Authors:
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F Fontana; P Bernardi; E M Pich; L Tartuferi; S Boschi; S Spampinato |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Peptides Volume: 21 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-11-06 Completed Date: 2000-12-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1223-30 Citation Subset: IM |
Affiliation:
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Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Ospedale S. Orsola, Via Massarenti 9, 40138 Bologna, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Blood Pressure / drug effects Catecholamines / blood Enkephalin, Methionine / blood Female Heart Rate / drug effects Humans Hydrogen-Ion Concentration Hyperventilation / drug therapy* Male Naloxone / pharmacology Opioid Peptides / pharmacology* Time Factors beta-Endorphin / blood |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Opioid Peptides; 465-65-6/Naloxone; 58569-55-4/Enkephalin, Methionine; 60617-12-1/beta-Endorphin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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