Document Detail

Opioid-monoamine interactions in spinal antinociception: evidence for serotonin but not norepinephrine reciprocity.
MedLine Citation:
PMID:  2841636     Owner:  NLM     Status:  MEDLINE    
Anatomical and electrophysiological studies have demonstrated that enkephalinergic, noradrenergic, and serotonergic pathways projecting from the brain-stem to the dorsal horn inhibit nociceptive transmission at the spinal level. Previous attempts to delineate interactions between opioids, norepinephrine (NE), and serotonin (5-HT) in the production of spinal analgesia have produced conflicting results. The present study determined the effect of intrathecal (i.t.) pretreatment with opioid, NE, and 5-HT antagonists upon i.t. monoamine- and morphine-induced antinociception as assessed with the rat tail-flick model. Naloxone, at a dose which antagonized i.t. morphine analgesia, had no effect upon i.t. NE but inhibited i.t. 5-HT antinociception. Corynanthine or yohimbine (NE antagonists) reduced analgesia elicited by i.t. NE but not morphine, while pretreatment with methysergide or ketanserin (5-HT antagonists) attenuated both i.t. 5-HT- and morphine-induced antinociception. These results suggest that (1) an opioid link mediates spinal 5-HT but not NE antinociception, and (2) 5-HT but not NE participates in spinal morphine analgesia.
D E Kellstein; R T Malseed; F J Goldstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pain     Volume:  34     ISSN:  0304-3959     ISO Abbreviation:  Pain     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-09-22     Completed Date:  1988-09-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  85-92     Citation Subset:  IM    
Department of Pharmacology and Toxicology, Philadelphia College of Pharmacy and Science, PA 19104.
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MeSH Terms
Endorphins / physiology*
Norepinephrine / physiology*
Pain / physiopathology*
Rats, Inbred Strains
Serotonin / physiology*
Spinal Cord / physiology*
Synaptic Transmission
Reg. No./Substance:
0/Endorphins; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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