| Opioid modulation of ingestive behaviors in woodchucks and racoons. | |
| | |
MedLine Citation:
|
PMID: 2987986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have examined the effect on feeding of opioid blockade with naloxone in two species which demonstrate a marked seasonality in their feeding patterns, the racoon (Procyon lotor) and the woodchuck (Marmota monax). Naloxone suppressed food intake in the woodchuck which is a true hibernator. Naloxone failed to suppress food intake in the racoon and, in fact, enhanced intake of a preferred sucrose solution. In the racoon, ir-dynorphine concentrations were extremely high in the hypothalamus compared to the values obtained in rats and woodchucks. We suggest that possible explanations for the lack of responsiveness to opiates in racoons may be their extremely high daily food intake relatively to body mass when compared to woodchucks and rats and the high levels of ir-dynorphin may be sufficient to overcome the inhibitory effect of naloxone. These studies stress the occurrence of species diversity in the response to opioid antagonism. |
| | |
Authors:
|
S E Nizielski; J E Morley; B A Gosnell; U S Seal; A S Levine |
Related Documents
:
|
3513216 - Effects of manipulations of glucoregulation on feeding in the ground squirrel. 1335266 - Paraventricular hypothalamic clonidine increases rather than decreases susceptibility t... 22947916 - Modulation of sweet responses of taste receptor cells. 19232396 - Central administration of metastin increases food intake through opioid neurons in chicks. 13698026 - Production of polydipsia in normal rats by an intermittent food schedule. 14988456 - Concentrations of proanthocyanidins in common foods and estimations of normal consumption. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Physiology & behavior Volume: 34 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 1985 Feb |
Date Detail:
|
Created Date: 1985-06-28 Completed Date: 1985-06-28 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 171-6 Citation Subset: IM; S |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Weight / drug effects Drinking / drug effects Eating / drug effects* Endorphins / physiology* Hibernation / drug effects Male Marmota Naloxone / pharmacology* Raccoons Receptors, Opioid / drug effects* Seasons Taste / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Endorphins; 0/Receptors, Opioid; 465-65-6/Naloxone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Motor responses of cyproterone acetate-treated rat vas deferens to electrical field stimulation, nor...
Next Document: Conditioned taste aversion suppresses induction of delayed-type hypersensitivity immune reactions.