Document Detail

Opioid modulation of ingestive behaviors in woodchucks and racoons.
MedLine Citation:
PMID:  2987986     Owner:  NLM     Status:  MEDLINE    
We have examined the effect on feeding of opioid blockade with naloxone in two species which demonstrate a marked seasonality in their feeding patterns, the racoon (Procyon lotor) and the woodchuck (Marmota monax). Naloxone suppressed food intake in the woodchuck which is a true hibernator. Naloxone failed to suppress food intake in the racoon and, in fact, enhanced intake of a preferred sucrose solution. In the racoon, ir-dynorphine concentrations were extremely high in the hypothalamus compared to the values obtained in rats and woodchucks. We suggest that possible explanations for the lack of responsiveness to opiates in racoons may be their extremely high daily food intake relatively to body mass when compared to woodchucks and rats and the high levels of ir-dynorphin may be sufficient to overcome the inhibitory effect of naloxone. These studies stress the occurrence of species diversity in the response to opioid antagonism.
S E Nizielski; J E Morley; B A Gosnell; U S Seal; A S Levine
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  34     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-06-28     Completed Date:  1985-06-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  171-6     Citation Subset:  IM; S    
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MeSH Terms
Body Weight / drug effects
Drinking / drug effects
Eating / drug effects*
Endorphins / physiology*
Hibernation / drug effects
Naloxone / pharmacology*
Receptors, Opioid / drug effects*
Taste / drug effects
Reg. No./Substance:
0/Endorphins; 0/Receptors, Opioid; 465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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