Document Detail

Opioid inhibition of cholinergic transmission in the guinea-pig ileum is independent of intracellular cyclic AMP.
MedLine Citation:
PMID:  1694775     Owner:  NLM     Status:  MEDLINE    
This study examined whether the inhibitory actions of opioids in the guinea-pig ileum were influenced by agents which mimic or elevate intracellular cyclic adenosine 3',5'-monophosphate (cyclic AMP) levels. In longitudinal muscle-myenteric plexus preparations, the mu agonist, [D-Ala2,NMePhe4,Gly-ol5]enkephalin (DAGO) and the kappa agonist, dynorphin A-(1-13) depressed contractions of the longitudinal muscle evoked by electrical stimulation of myenteric neurons. Mean IC50 values were 19 and 2.8 nM for DAGO and dynorphin, respectively. Neither forskolin, cholera toxin nor dibutyryl cyclic AMP affected significantly the IC50s for the opioid agonists. The experiments suggest that mu and kappa agonists inhibit excitatory cholinergic transmission to the longitudinal muscle by intracellular effector mechanisms that do not involve cyclic AMP.
S M Johnson
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  180     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-13     Completed Date:  1990-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  331-8     Citation Subset:  IM    
Department of Physiology, Flinders University of South Australia, Bedford Park.
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MeSH Terms
1-Methyl-3-isobutylxanthine / pharmacology
Bucladesine / pharmacology
Carbachol / pharmacology
Cholera Toxin / pharmacology
Cyclic AMP / physiology*
Dynorphins / pharmacology
Electric Stimulation
Forskolin / pharmacology
Guinea Pigs
Ileum / drug effects,  innervation,  metabolism
Narcotics / pharmacology*
Parasympathetic Nervous System / drug effects*,  metabolism
Receptors, Opioid / metabolism
Receptors, Opioid, kappa
Receptors, Opioid, mu
Synaptic Transmission / drug effects*
Reg. No./Substance:
0/Narcotics; 0/Receptors, Opioid; 0/Receptors, Opioid, kappa; 0/Receptors, Opioid, mu; 28822-58-4/1-Methyl-3-isobutylxanthine; 362-74-3/Bucladesine; 51-83-2/Carbachol; 60-92-4/Cyclic AMP; 66428-89-5/Forskolin; 74913-18-1/Dynorphins; 9012-63-9/Cholera Toxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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