Document Detail

Opioid effects on intake of sweet solutions depend both on prior drug experience and on prior ingestive experience.
MedLine Citation:
PMID:  2241139     Owner:  NLM     Status:  MEDLINE    
Two experiments investigated the effect of opioids on ingestion of sweet solutions in non-deprived rats. Experiment 1 replicated previous work from our laboratory showing virtually complete inhibition of sucrose and saccharin intake during 10 days of daily naloxone treatment. During recovery, prior naloxone experience significantly stimulated sucrose intake but had no effect on saccharin intake. In the absence of naloxone treatment, ingestive experience alone reduced naloxone's typical intake-suppressant effect. These findings suggest that drug experience and ingestive experience may interact to determine the intake-suppressant effect of naloxone. Experiment 2 examined the effects of opioid agonists on sucrose ingestion during 10 days of initial drug treatment and 5 days of recovery. A low dose of the kappa agonist U-50,488H significantly stimulated sucrose ingestion during the drug treatment period and this effect persisted for several days after treatment ended. Initial (non-significant) intake suppressant effects of the mu agonist morphine or a high dose of U-50,488H tended to decrease with repeated testing and did not reappear during recovery. These data suggest that in addition to immediate, direct effects on motivation, opioids may affect long-term changes in responsiveness to sweet tastes.
W C Lynch; G Burns
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Appetite     Volume:  15     ISSN:  0195-6663     ISO Abbreviation:  Appetite     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-12-07     Completed Date:  1990-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  23-32     Citation Subset:  IM    
Department of Psychology, Montana State University.
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MeSH Terms
Drug Administration Schedule
Drug Interactions
Eating / drug effects*
Naloxone / antagonists & inhibitors,  pharmacology*
Narcotics / pharmacology
Rats, Inbred Strains
Saccharin / pharmacology*
Sucrose / pharmacology*
Reg. No./Substance:
0/Narcotics; 465-65-6/Naloxone; 57-50-1/Sucrose; 81-07-2/Saccharin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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