Document Detail

Opioid δ(1) and δ(2) Receptor Agonist Attenuate Myocardial Injury Via mPTP in Rats With Acute Hemorrhagic Shock.
MedLine Citation:
PMID:  20444473     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Studies have documented the beneficial roles of δ opioid receptor (OR) agonist for hemorrhagic shock. However, the myocardial protection roles and the mechanisms of hemodynamic stability during resuscitation of δ-OR agonist have not been explored. This study was designed to investigate myocardial protective effects and the mechanisms of high selective δ(1) and δ(2)-OR agonists during resuscitation of acute hemorrhagic shock.
MATERIALS AND METHODS: Forty-eight adult male SD rats were adopted 60-min hemorrhagic shock through removing 30% (5mL) of the total blood volume, and followed by 2-h resuscitation with shed blood and L-lactated Ringer's solution. At the end of shock and prior to resuscitation, NS, δ(1)-OR agonist TAN-67 (10mg/kg) and antagonist BNTX (3mg/kg), and BNTX+TAN-67, DMSO, δ(2)-OR agonist Deltorphin II (1mg/kg) and antagonist NTB (2mg/kg), and NTB+Deltorphin II in 0.5mL were administrated. Left ventricular function parameters were measured during the whole experimental period. Myocardial mitochondria were isolated to determine opening of mitochondrial permeability transition pore (mPTP). Morphologic changes in myocardium and mitochondria were observed by electron microscope.
RESULTS: The hemodynamic indexes in group TAN-67 and group Deltorphin II were higher than control group at each time point during resuscitation, respectively (P<0.05). TAN-67 and Deltorphin II decrease but their antagonists BNTX and NTB increase the opening of mPTP (P<0.05). Myocardial and mitochondrial damage were attenuated in group TAN-67 and group Deltorphin II.
CONCLUSIONS: δ(1)-OR agonist TAN-67 and δ(2)-OR agonist Deltorphin II protect the heart by targeting the mPTP in rats with acute hemorrhagic shock.
Xiaoli Zeng; Xiaoling Zhao; Yonghui Yang; Jianke Kuai; Changjun Gao; Daihua Yu; Hui Zhao; Wei Chai; Linong Yao
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Publication Detail:
Type:  Journal Article     Date:  2010-01-14
Journal Detail:
Title:  The Journal of surgical research     Volume:  169     ISSN:  1095-8673     ISO Abbreviation:  J. Surg. Res.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-76     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Anesthesiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
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