Document Detail

Opinion: Building epithelial architecture: insights from three-dimensional culture models.
MedLine Citation:
PMID:  12094219     Owner:  NLM     Status:  MEDLINE    
How do individual cells organize into multicellular tissues? Here, we propose that the morphogenetic behaviour of epithelial cells is guided by two distinct elements: an intrinsic differentiation programme that drives formation of a lumen-enclosing monolayer, and a growth factor-induced, transient de-differentiation that allows this monolayer to be remodelled.
Lucy Erin O'Brien; Mirjam M P Zegers; Keith E Mostov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  3     ISSN:  1471-0072     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-02     Completed Date:  2002-08-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  531-7     Citation Subset:  IM    
Department of Anatomy, and the Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA.
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MeSH Terms
Cell Communication
Cell Culture Techniques / methods
Cell Differentiation
Cell Division / drug effects
Epithelial Cells / cytology*,  drug effects
Hepatocyte Growth Factor / pharmacology
Reg. No./Substance:
67256-21-7/Hepatocyte Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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