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Opiates and the development of post-injury complications: a review.
MedLine Citation:
PMID:  19079686     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Opiates are the analgesic of choice for the treatment of post-burn, -trauma and -surgical pain, however, it is also well-established that opiates can induce immune complications. These complications, independent of the analgesic regime, are also associated with severe traumatic injuries, such as burns. Recent findings suggest that opiates can contribute to immune and infectious complications in experimental and clinical settings. Based on the immunomodulatory properties of opiate analgesics their therapeutic use/misuse post-injury may contribute to the development of complications leading to increased morbidity and mortality in this patient population. An improved understanding of the relationship(s) between opiates and complications following major injury, such as burn trauma is likely to contribute towards an improvement in existing, as well as the development of new therapeutic regimes. This review will focus on the role of opiate analgesic usage and abuse and in the development of complications following major traumatic injury with a particular emphasis on burn injury.
Authors:
Martin G Schwacha
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Publication Detail:
Type:  Journal Article     Date:  2008-01-20
Journal Detail:
Title:  International journal of clinical and experimental medicine     Volume:  1     ISSN:  1940-5901     ISO Abbreviation:  Int J Clin Exp Med     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-16     Completed Date:  2011-07-14     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  101471010     Medline TA:  Int J Clin Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  42-9     Citation Subset:  -    
Affiliation:
Department of Surgery and Pathology, University of Alabama at Birmingham Birmingham, AL 35852, USA.
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