Document Detail

Opiate antagonists stereoselectively attenuate the consumption of food but not of water by pigeons.
MedLine Citation:
PMID:  6504949     Owner:  NLM     Status:  MEDLINE    
Three experiments were performed to evaluate the influence of the two opiate antagonists, naloxone HCl (NAL) and Mr 2266, on the ingestive behavior of domestic pigeons. In the first and second experiments, these drugs were administered at 3 doses (0.25, 1 and 4 mg) to non-deprived and to 24 hr-fasted pigeons, respectively. Measure of the food and water consumption of the birds for up to 6 hrs post-injection revealed that as compared to control values, administration of both antagonists attenuated feeding without reducing drinking. Administration of both drugs produced a rather similar anorexic effect, with the difference that Mr 2266 tended to decrease the food intake for a longer period of time than did NAL. In the third experiment, the food consumption of fasted pigeons was reduced by the injection of Mr 2266, but not of its (+) stereoisomer Mr 2267, showing that the behavioral influence of Mr 2266 is stereoselective. Confronted with other studies, these results suggest that in pigeons, opiate receptors participate in the regulation of the food consumption without playing a major role in the control of the water intake.
P Deviche; A Wohland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  21     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-12-26     Completed Date:  1984-12-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  507-12     Citation Subset:  IM    
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MeSH Terms
Benzomorphans / pharmacology
Drinking Behavior / drug effects*
Feeding Behavior / drug effects*
Food Deprivation
Naloxone / pharmacology
Narcotic Antagonists / pharmacology*
Time Factors
Reg. No./Substance:
0/Benzomorphans; 0/Narcotic Antagonists; 465-65-6/Naloxone; 56649-76-4/MR 2266

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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