Document Detail

Opiate agonists and antagonists modulate taste perception in opiate-maintained and recently detoxified subjects.
MedLine Citation:
PMID:  23364815     Owner:  NLM     Status:  MEDLINE    
Heroin addicts consume large quantities of refined sugars. This study investigated the effect of opiate use and antagonism on sweet taste in opiate-maintained drug users and detoxified former chronic opiate users, using a within-subject design. Seven opiate users received methadone and seven buprenorphine maintenance. Six detoxified subjects received naltrexone. Sucrose recognition thresholds and measurements of pleasantness and intensity were determined before and four hours after 1) a single dose of methadone or buprenorphine or 2) naltrexone. Control data were taken from a cohort of healthy volunteers including smokers. All measures of sweet and salt taste perception were significantly greater in opiate users and recently detoxified subjects compared to control subjects, with the exception of sweet pleasantness, which returned to control level after detoxification. Acute methadone administration reduced salt thresholds and unpleasantness to control levels. Increased sweet thresholds and salt unpleasantness in detoxified subjects were reversed by acute opioid antagonism, returning to control levels. These results suggest that opiate use and antagonism alters taste perception. Some of the alterations reverse on detoxification (sweet pleasantness), and others can be reversed by opioid antagonism (sweet threshold, salt unpleasantness). Changes in taste perception may underlie altered consumption of refined sugars in opiate users.
Amy Green; Arun Kaul; Jacinta O'Shea; Ekta Sharma; Lisa Bennett; Emma L Mullings; Marcus R Munafò; David J Nutt; Jan K Melichar; Lucy F Donaldson
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2013-01-29
Journal Detail:
Title:  Journal of psychopharmacology (Oxford, England)     Volume:  27     ISSN:  1461-7285     ISO Abbreviation:  J. Psychopharmacol. (Oxford)     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-20     Completed Date:  2013-08-16     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8907828     Medline TA:  J Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-75     Citation Subset:  IM    
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MeSH Terms
Analgesics, Opioid / adverse effects*,  therapeutic use
Buprenorphine / adverse effects,  therapeutic use
Cohort Studies
Cross-Over Studies
Dietary Sucrose / adverse effects,  metabolism
Double-Blind Method
Food Preferences / drug effects
Methadone / adverse effects,  therapeutic use
Naltrexone / adverse effects,  therapeutic use
Narcotic Antagonists / adverse effects*,  therapeutic use
Opiate Substitution Treatment / adverse effects*
Opioid-Related Disorders / drug therapy*,  metabolism
Osmolar Concentration
Sodium Chloride, Dietary / adverse effects,  metabolism
Taste Perception / drug effects*
Taste Threshold / drug effects
Young Adult
Grant Support
G1002226//Medical Research Council
Reg. No./Substance:
0/Analgesics, Opioid; 0/Dietary Sucrose; 0/Narcotic Antagonists; 0/Sodium Chloride, Dietary; 40D3SCR4GZ/Buprenorphine; 5S6W795CQM/Naltrexone; UC6VBE7V1Z/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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