Document Detail


Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics.
MedLine Citation:
PMID:  23023708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Addictive diseases, including addiction to heroin, prescription opioids, or cocaine, pose massive personal and public health costs. Addictions are chronic relapsing diseases of the brain caused by drug-induced direct effects and persisting neuroadaptations at the epigenetic, mRNA, neuropeptide, neurotransmitter, or protein levels. These neuroadaptations, which can be specific to drug type, and their resultant behaviors are modified by various internal and external environmental factors, including stress responsivity, addict mindset, and social setting. Specific gene variants, including variants encoding pharmacological target proteins or genes mediating neuroadaptations, also modify vulnerability at particular stages of addiction. Greater understanding of these interacting factors through laboratory-based and translational studies have the potential to optimize early interventions for the therapy of chronic addictive diseases and to reduce the burden of relapse. Here, we review the molecular neurobiology and genetics of opiate addiction, including heroin and prescription opioids, and cocaine addiction.
Authors:
Mary Jeanne Kreek; Orna Levran; Brian Reed; Stefan D Schlussman; Yan Zhou; Eduardo R Butelman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-10-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-02-01     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3387-93     Citation Subset:  AIM; IM    
Affiliation:
Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10065, USA. kreek@rockefeller.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Basal Ganglia / drug effects,  physiopathology
Cocaine-Related Disorders / drug therapy,  genetics,  physiopathology*
Dopamine / physiology
Dopaminergic Neurons / physiology
Gene Expression Regulation / drug effects
Genetic Predisposition to Disease
Humans
Hypothalamo-Hypophyseal System / physiopathology
Limbic System / drug effects,  physiopathology
Methadone / therapeutic use
Mice
Mice, Knockout
Neuropeptides / physiology
Opioid-Related Disorders / drug therapy,  genetics,  physiopathology*
Pharmacogenetics
Pituitary-Adrenal System / physiopathology
Rats
Receptors, Dopamine / drug effects,  genetics,  physiology
Receptors, Opioid / drug effects,  physiology
Receptors, Opioid, mu / drug effects,  genetics,  physiology
Reward
Stress, Physiological
Stress, Psychological / physiopathology
Grant Support
ID/Acronym/Agency:
P60-DA05130/DA/NIDA NIH HHS; R21-DA031990/DA/NIDA NIH HHS; UL1 TR000043/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Neuropeptides; 0/OPRM1 protein, human; 0/Receptors, Dopamine; 0/Receptors, Opioid; 0/Receptors, Opioid, mu; 76-99-3/Methadone
Comments/Corrections

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