| Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics. | |
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MedLine Citation:
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PMID: 23023708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Addictive diseases, including addiction to heroin, prescription opioids, or cocaine, pose massive personal and public health costs. Addictions are chronic relapsing diseases of the brain caused by drug-induced direct effects and persisting neuroadaptations at the epigenetic, mRNA, neuropeptide, neurotransmitter, or protein levels. These neuroadaptations, which can be specific to drug type, and their resultant behaviors are modified by various internal and external environmental factors, including stress responsivity, addict mindset, and social setting. Specific gene variants, including variants encoding pharmacological target proteins or genes mediating neuroadaptations, also modify vulnerability at particular stages of addiction. Greater understanding of these interacting factors through laboratory-based and translational studies have the potential to optimize early interventions for the therapy of chronic addictive diseases and to reduce the burden of relapse. Here, we review the molecular neurobiology and genetics of opiate addiction, including heroin and prescription opioids, and cocaine addiction. |
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Authors:
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Mary Jeanne Kreek; Orna Levran; Brian Reed; Stefan D Schlussman; Yan Zhou; Eduardo R Butelman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2012-10-01 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 122 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-01 Completed Date: 2013-02-01 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 3387-93 Citation Subset: AIM; IM |
Affiliation:
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Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10065, USA. kreek@rockefeller.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basal Ganglia / drug effects, physiopathology Cocaine-Related Disorders / drug therapy, genetics, physiopathology* Dopamine / physiology Dopaminergic Neurons / physiology Gene Expression Regulation / drug effects Genetic Predisposition to Disease Humans Hypothalamo-Hypophyseal System / physiopathology Limbic System / drug effects, physiopathology Methadone / therapeutic use Mice Mice, Knockout Neuropeptides / physiology Opioid-Related Disorders / drug therapy, genetics, physiopathology* Pharmacogenetics Pituitary-Adrenal System / physiopathology Rats Receptors, Dopamine / drug effects, genetics, physiology Receptors, Opioid / drug effects, physiology Receptors, Opioid, mu / drug effects, genetics, physiology Reward Stress, Physiological Stress, Psychological / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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P60-DA05130/DA/NIDA NIH HHS; R21-DA031990/DA/NIDA NIH HHS; UL1 TR000043/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptides; 0/OPRM1 protein, human; 0/Receptors, Dopamine; 0/Receptors, Opioid; 0/Receptors, Opioid, mu; 76-99-3/Methadone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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