Document Detail


Ophthalmoplegic migraine: amelioration by Flufenamic acid, a prostaglandin inhibitor.
MedLine Citation:
PMID:  331178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It was recently suggested that prostaglandins' release (especially PGE1 and PGF2alpha) play a key role in the development of the migrainous attack. Based on this hypothesis a therapeutic trial with flufenamic acid (a prostaglandin inhibitor of the fenamates group) was conducted during 1 year in 5 patients suffering from recurrent ophthalmoplegic migraine. We treated 25 migrainous attacks; in 22 of them the patients reported marked alleviation of the headaches and only in two occasions a partial third nerve palsy accompanied the attack.
Authors:
J M Rabey; Y Vardi; D Van Dyck; M Streifler
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde     Volume:  175     ISSN:  0030-3755     ISO Abbreviation:  Ophthalmologica     Publication Date:  1977  
Date Detail:
Created Date:  1977-10-20     Completed Date:  1977-10-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0054655     Medline TA:  Ophthalmologica     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  148-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Clinical Trials as Topic
Drug Evaluation
Female
Flufenamic Acid / therapeutic use*
Follow-Up Studies
Humans
Male
Migraine Disorders / complications,  drug therapy*,  physiopathology
Ophthalmoplegia / complications*,  physiopathology
Prostaglandins / physiology
Chemical
Reg. No./Substance:
0/Prostaglandins; 530-78-9/Flufenamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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