Document Detail

Ophthalmoplegic "migraine" or recurrent ophthalmoplegic cranial neuropathy: new cases and a systematic review.
MedLine Citation:
PMID:  22241707     Owner:  NLM     Status:  MEDLINE    
Ophthalmoplegic migraine is a poorly understood neurologic syndrome characterized by recurrent bouts of head pain and ophthalmoplegia. By reviewing cases presenting to our centers in whom the phenotype has been carefully dissected, and systematically reviewing all published cases of ophthalmoplegic migraine in the magnetic resonance imaging (MRI) era, this review sets out to clearly define the syndrome and discuss possible etiologies. We found that in up to one-third of patients, the headache was not migrainous or associated with migrainous symptoms. In three-quarters of the cases involving the third nerve, there was focal nerve thickening and contrast enhancement on MRI. Observational data suggest systemic corticosteroids may be beneficial acutely. The etiology remains unclear, but may involve recurrent bouts of demyelination of the oculomotor nerve. "Ophthalmoplegic migraine" is a misnomer in that it is probably not a variant of migraine but rather a recurrent cranial neuralgia. A more appropriate name might be "ophthalmoplegic cranial neuropathy."
Amy A Gelfand; Jeffrey M Gelfand; Prab Prabakhar; Peter J Goadsby
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-01-12
Journal Detail:
Title:  Journal of child neurology     Volume:  27     ISSN:  1708-8283     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-18     Completed Date:  2012-09-18     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  759-66     Citation Subset:  IM    
Division of Child Neurology, Department of Neurology, University of California, San Francisco, CA, USA.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Cranial Nerve Diseases / cerebrospinal fluid,  complications*,  drug therapy
Databases, Bibliographic / statistics & numerical data
Magnetic Resonance Imaging
Ophthalmoplegia / cerebrospinal fluid,  complications*,  drug therapy
Ophthalmoplegic Migraine / cerebrospinal fluid,  complications*,  drug therapy
Young Adult
Grant Support
K12 NS001692/NS/NINDS NIH HHS; //Medical Research Council
Reg. No./Substance:
0/Adrenal Cortex Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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