| The ophthalmologist's role in the management of acute Stevens-Johnson syndrome and toxic epidermal necrolysis. | |
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MedLine Citation:
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PMID: 20964982 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Stevens-Johnson syndrome (SJS) and its more severe variant, toxic epidermal necrolysis (TEN), are relatively rare but have high mortality rates. Survivors are frequently afflicted with severe blinding ocular surface diseases. Recent literature in the areas of ophthalmology and dermatology illustrate that the ophthalmologist's role should no longer be considered secondary in the acute management of SJS/TEN. Accurately differentiating SJS or TEN from erythema multiforme majus (EMM) at the onset of the disease is important, because the management approach to these disease entities differs. Systemic cyclosporine and intravenous immunoglobulin have shown some potential as treatments for SJS/TEN, but their efficacies remain controversial. Amniotic membrane transplantation and intravenous corticosteroid pulse therapy at the acute stage have shown promise for preventing late sight-threatening cicatricial complications. An improved staging system for the ocular surface involvement of acute SJS/TEN, as well as better understanding of the underlying destructive pathogenic mechanism, should further improve our ability to predict ocular involvement and develop new therapeutics to abort destructive processes at the acute stage. |
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Authors:
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Yao Fu; Darren G Gregory; Kimberly C Sippel; Charles S Bouchard; Scheffer C G Tseng |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The ocular surface Volume: 8 ISSN: 1542-0124 ISO Abbreviation: Ocul Surf Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101156063 Medline TA: Ocul Surf Country: United States |
Other Details:
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Languages: eng Pagination: 193-203 Citation Subset: IM |
Affiliation:
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Ocular Surface Center and Ocular Surface Research & Education Foundation, Miami, FL 33173, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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