Document Detail


Operative risk factors in the metabolic syndrome: is it lipids and high blood pressure or are there direct vascular effects of insulin resistance and obesity?
MedLine Citation:
PMID:  17059794     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The metabolic syndrome is associated with an increased risk for cardiovascular disease. Dyslipidemia, high blood pressure, and impaired glucose tolerance, components of the metabolic syndrome, are all clearly atherogenic. Insulin resistance is an important correlate of other risk factors. Excess abdominal fat, as often seen in overweight people and commonly observed in obese individuals, is the single most important central feature of the metabolic syndrome. In addition to insulin resistance, an excess amount of abdominal fat is associated with all the features of metabolic clustering. Adipocytes secrete several peptide hormones that have been related to the metabolic syndrome and related cardiovascular disease. The role of traditional versus novel adipose tissue-related risk factors in the background of atherosclerosis in the metabolic syndrome are discussed.
Authors:
Olavi Ukkola
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current cardiology reports     Volume:  8     ISSN:  1523-3782     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-24     Completed Date:  2007-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-32     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Biocenter Oulu, University of Oulu, Kajaanintie 50/P.O. Box 5000, Oulu, FIN-90014, Finland. olavi.ukkola@oulu.fi
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MeSH Terms
Descriptor/Qualifier:
Blood Vessels / physiopathology
Cardiovascular Diseases / etiology*
Humans
Hypertension / complications
Insulin Resistance
Lipids / blood
Metabolic Syndrome X / blood,  complications*,  physiopathology
Obesity / complications
Risk Factors
Chemical
Reg. No./Substance:
0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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