| Operation Everest III (Comex'97): the effect of simulated sever hypobaric hypoxia on lipid peroxidation and antioxidant defence systems in human blood at rest and after maximal exercise. | |
| | |
MedLine Citation:
|
PMID: 11723998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Eight subjects were placed in a decompression chamber for 31 days at pressures from sea level (SL) to 8848 m altitude equivalent. Whole blood lipid peroxidation (LP) was increased at 6000 m by a mean of 23% (P<0.05), at 8000 m by 79% (P<0.01) and at 8848 m by 94% (P<0.01). (All figures are means.) Two days after return to sea level (RSL), it remained high, by 81% (P<0.01), while corresponding erythrocyte GSH/GSSG ratios decreased by 31, 46, 49, 48%, respectively (each P<0.01). Erythrocyte SOD and plasma ascorbate did not change significantly. At sea level, maximal exercise induced a 49% increase in LP (P<0.01), and a 27% decrease in erythrocyte GSH/GSSG ratio relative to resting values (P<0.05). At 6000 m, the LP was enhanced further from 23 (P<0.05) to 66% (P<0.01), and after RSL from 81 (P<0.01) to 232% (P<0.01), while pre-exercise GSH/GSSG ratios did not change significantly. Exercise did not change plasma ascorbate relative to sea level or to 6000 m, but decreased after RSL by 32% (P<0.01). These findings suggest that oxidative stress is induced by prolonged hypobaric hypoxia, and is maintained by rapid return to sea level, similar to the post-hypoxic re-oxygenation process. It is increased by physical exercise. |
| | |
Authors:
|
P Joanny; J Steinberg; P Robach; J P Richalet; C Gortan; B Gardette; Y Jammes |
Related Documents
:
|
16239468 - Ice-sheet and sea-level changes. 11537198 - Strontium isotopic variations of neoproterozoic seawater: implications for crustal evol... 15813148 - Tibetans at extreme altitude. 4061578 - Maximal exercise capacity in adolescent european and amerindian high-altitude natives. 17146318 - Exercise in the heat: effect of fluid ingestion on blood-brain barrier permeability. 10656978 - Biexponential recovery model of lumbar viscoelastic laxity and reflexive muscular activ... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Resuscitation Volume: 49 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 2001 Jun |
Date Detail:
|
Created Date: 2001-11-27 Completed Date: 2002-01-03 Revised Date: 2009-08-25 |
Medline Journal Info:
|
Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
|
Languages: eng Pagination: 307-14 Citation Subset: IM |
Affiliation:
|
INSERM U 501, Interactions Fonctionnelles en Neuroendocrinologie, Institut Jean Roche, Faculté de Médecine de Marseilles, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acclimatization
/
physiology* Adult Altitude* Anoxia / blood Antioxidants / metabolism* Ascorbic Acid / blood Circadian Rhythm / physiology Erythrocytes / metabolism Exercise / physiology* France Glutathione / blood Hematocrit Humans Hyperbaric Oxygenation* Lipid Peroxidation / physiology Male Oxidative Stress / physiology* Oxygen Consumption / physiology Reference Values Rest / physiology* Severity of Illness Index Superoxide Dismutase / blood Thiobarbituric Acid Reactive Substances / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Thiobarbituric Acid Reactive Substances; 50-81-7/Ascorbic Acid; 70-18-8/Glutathione; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of three wheelchair cushions for effectiveness of pressure relief.
Next Document: Severe respiratory failure following charcoal application in a toddler.