Document Detail

Operation Everest III (Comex'97): the effect of simulated sever hypobaric hypoxia on lipid peroxidation and antioxidant defence systems in human blood at rest and after maximal exercise.
MedLine Citation:
PMID:  11723998     Owner:  NLM     Status:  MEDLINE    
Eight subjects were placed in a decompression chamber for 31 days at pressures from sea level (SL) to 8848 m altitude equivalent. Whole blood lipid peroxidation (LP) was increased at 6000 m by a mean of 23% (P<0.05), at 8000 m by 79% (P<0.01) and at 8848 m by 94% (P<0.01). (All figures are means.) Two days after return to sea level (RSL), it remained high, by 81% (P<0.01), while corresponding erythrocyte GSH/GSSG ratios decreased by 31, 46, 49, 48%, respectively (each P<0.01). Erythrocyte SOD and plasma ascorbate did not change significantly. At sea level, maximal exercise induced a 49% increase in LP (P<0.01), and a 27% decrease in erythrocyte GSH/GSSG ratio relative to resting values (P<0.05). At 6000 m, the LP was enhanced further from 23 (P<0.05) to 66% (P<0.01), and after RSL from 81 (P<0.01) to 232% (P<0.01), while pre-exercise GSH/GSSG ratios did not change significantly. Exercise did not change plasma ascorbate relative to sea level or to 6000 m, but decreased after RSL by 32% (P<0.01). These findings suggest that oxidative stress is induced by prolonged hypobaric hypoxia, and is maintained by rapid return to sea level, similar to the post-hypoxic re-oxygenation process. It is increased by physical exercise.
P Joanny; J Steinberg; P Robach; J P Richalet; C Gortan; B Gardette; Y Jammes
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Resuscitation     Volume:  49     ISSN:  0300-9572     ISO Abbreviation:  Resuscitation     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-11-27     Completed Date:  2002-01-03     Revised Date:  2009-08-25    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  307-14     Citation Subset:  IM    
INSERM U 501, Interactions Fonctionnelles en Neuroendocrinologie, Institut Jean Roche, Faculté de Médecine de Marseilles, France.
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MeSH Terms
Acclimatization / physiology*
Anoxia / blood
Antioxidants / metabolism*
Ascorbic Acid / blood
Circadian Rhythm / physiology
Erythrocytes / metabolism
Exercise / physiology*
Glutathione / blood
Hyperbaric Oxygenation*
Lipid Peroxidation / physiology
Oxidative Stress / physiology*
Oxygen Consumption / physiology
Reference Values
Rest / physiology*
Severity of Illness Index
Superoxide Dismutase / blood
Thiobarbituric Acid Reactive Substances / metabolism
Reg. No./Substance:
0/Antioxidants; 0/Thiobarbituric Acid Reactive Substances; 50-81-7/Ascorbic Acid; 70-18-8/Glutathione; EC Dismutase

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