| Operant thermoregulation of rats with anterior hypothalamic lesions. | |
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MedLine Citation:
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PMID: 7329450 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relative importance of different effector mechanisms of thermoregulation may change depending on their availability. Intact rats make only limited use of a learned response on a cold ambient temperature stimulus, and rely almost entirely on autonomic regulatory functions. After destruction of the anterior hypothalamus, rats exhibit a reduced thermoregulatory capacity; i.e. body temperature drops in the cold and rises in the heat. Under this situation a conditioned operant behavior (lever pressing for increasing or decreasing ambient temperature) becomes an important factor to keep body temperature almost constant. Receptor blockers of some putative transmitters in central thermoregulatory pathways influence thermoregulation. Phentolamine induces hypothermia in intact rats in the cold. Hypothalamic lesions are additive in effect with with the drug. Pimozide has no effect neither in the cold nor in the heat intact and lesioned rats. Biperiden in the heat reinforces hyperthermia in intact and lesioned rats as well; in the cold the drug is ineffective. Performance of lesioned rats in an operant pain titration procedure does not differ from intact rats. |
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Authors:
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G Schulze; M Tetzner; H Topolinski |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 318 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1981 Dec |
Date Detail:
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Created Date: 1982-04-20 Completed Date: 1982-04-20 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 43-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biperiden / pharmacology Body Temperature Regulation* Body Weight Conditioning, Operant / physiology* Electroshock Female Hypothalamus / physiology* Hypothalamus, Anterior / physiology* Phentolamine / pharmacology Pimozide / pharmacology Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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2062-78-4/Pimozide; 50-60-2/Phentolamine; 514-65-8/Biperiden |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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