Document Detail


Operant behavior to obtain palatable food modifies ERK activity in the brain reward circuit.
MedLine Citation:
PMID:  22580057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Food palatability produces behavioral modifications that resemble those induced by drugs of abuse. Palatability-induced behavioral changes require both, the activation of the endogenous cannabinoid system, and changes in structural plasticity in neurons of the brain reward pathway. The ERK intracellular pathway is activated by CB1 receptors (CB1-R) and plays a crucial role in neuroplasticity. We investigated the activation of the ERK signaling cascade in the mesocorticolimbic system induced by operant training to obtain highly palatable isocaloric food and the involvement of the CB1-R in these responses. Using immunofluorescence techniques, we analyzed changes in ERK intracellular pathway activation in the mesocorticolimbic system of wild-type and CB1 knockout mice (CB1-/-) trained on an operant paradigm to obtain standard, highly caloric or highly palatable isocaloric food. Operant training for highly palatable isocaloric food, but not for standard or highly caloric food, produced a robust activation of the ERK signaling cascade in the same brain areas where this training modified structural plasticity. These changes induced by the operant training were absent in CB1-/-. We can conclude that the activation of the ERK pathway is associated to the neuroplasticity induced by operant training for highly palatable isocaloric food and might be involved in CB1-R mediated alterations in behavior and structural plasticity.
Authors:
Thomas Guegan; Laura Cutando; Giuseppe Gangarossa; Emanuela Santini; Gilberto Fisone; Albert Martinez; Emmanuel Valjent; Rafael Maldonado; Miquel Martin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-12
Journal Detail:
Title:  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology     Volume:  23     ISSN:  1873-7862     ISO Abbreviation:  Eur Neuropsychopharmacol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-08-19     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  9111390     Medline TA:  Eur Neuropsychopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  240-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. and ECNP. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Conditioning, Operant / physiology*
Feeding Behavior / physiology*
MAP Kinase Signaling System / physiology*
Male
Mice
Mice, Knockout
Neuronal Plasticity / physiology*
Nucleus Accumbens / metabolism*
Phosphorylation
Prefrontal Cortex / metabolism*
Receptor, Cannabinoid, CB1 / genetics
Reward
Signal Transduction / physiology
Chemical
Reg. No./Substance:
0/CNR1 protein, mouse; 0/Receptor, Cannabinoid, CB1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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