Document Detail


Opening ahead: early steps in lumen formation revealed.
MedLine Citation:
PMID:  21045801     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The contribution and order of polarity complexes and vesicular trafficking events during lumen formation remains obscure. Now, lumenogenesis in MDCK cell cysts is shown to require a Rab11a-Rabin8-Rab8a network that recruits Sec15A and Cdc42 and that promotes apical exocytosis by enlisting the Par complex and Sec8-Sec10 to an early apical membrane initiation site.
Authors:
Gerard Apodaca
Publication Detail:
Type:  Comment; News    
Journal Detail:
Title:  Nature cell biology     Volume:  12     ISSN:  1476-4679     ISO Abbreviation:  Nat. Cell Biol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-03     Completed Date:  2010-12-15     Revised Date:  2012-06-15    
Medline Journal Info:
Nlm Unique ID:  100890575     Medline TA:  Nat Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1026-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Cell Membrane / metabolism
Dogs
Epithelial Cells / cytology,  metabolism*
Kidney / cytology,  embryology*
Models, Biological
Morphogenesis*
Protein-Serine-Threonine Kinases / metabolism
cdc42 GTP-Binding Protein / metabolism
rab GTP-Binding Proteins / metabolism
Chemical
Reg. No./Substance:
EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/germinal center kinases; EC 3.6.1.-/rab GTP-Binding Proteins; EC 3.6.1.-/rab11 protein; EC 3.6.5.2/cdc42 GTP-Binding Protein
Comments/Corrections
Comment On:
Nat Cell Biol. 2010 Nov;12(11):1035-45   [PMID:  20890297 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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