| Open maintenance treatment of bipolar disorder spectrum patients who responded to gabapentin augmentation in the acute phase of treatment. | |
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MedLine Citation:
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PMID: 10628894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report describes the results of maintenance treatment with gabapentin in 18 previously refractory Bipolar Disorder patients who initially responded to augmentation with gabapentin during the acute phase of their therapy. Seven of the original 18 patients (39%) have continued to experience benefit from maintenance gabapentin treatment. Only three patients had to discontinue the gabapentin because of side effects. None of the 18 patients experienced an obvious significant adverse drug-drug interaction. Five of the patients discontinued gabapentin because of diminished clinical efficacy after a significant period of positive therapeutic effect. The results of this small open study suggest that gabapentin may be effective as an augmenting agent in the maintenance phase of treatment of some bipolar spectrum patients. |
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Authors:
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C B Schaffer; L C Schaffer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of affective disorders Volume: 55 ISSN: 0165-0327 ISO Abbreviation: J Affect Disord Publication Date: 1999 Oct |
Date Detail:
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Created Date: 2000-04-21 Completed Date: 2000-04-21 Revised Date: 2009-09-28 |
Medline Journal Info:
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Nlm Unique ID: 7906073 Medline TA: J Affect Disord Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 237-40 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, UC Davis School of Medicine, Sacramento, CA 95816, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acids
/
adverse effects,
pharmacology,
therapeutic use* Acute Disease Adult Amines* Antimanic Agents / adverse effects, pharmacology, therapeutic use* Bipolar Disorder / drug therapy*, psychology Cyclohexanecarboxylic Acids* Female Follow-Up Studies Humans Male Middle Aged Recurrence Treatment Outcome gamma-Aminobutyric Acid* |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 0/Amines; 0/Antimanic Agents; 0/Cyclohexanecarboxylic Acids; 56-12-2/gamma-Aminobutyric Acid; 60142-96-3/gabapentin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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