Document Detail

Open maintenance treatment of bipolar disorder spectrum patients who responded to gabapentin augmentation in the acute phase of treatment.
MedLine Citation:
PMID:  10628894     Owner:  NLM     Status:  MEDLINE    
This report describes the results of maintenance treatment with gabapentin in 18 previously refractory Bipolar Disorder patients who initially responded to augmentation with gabapentin during the acute phase of their therapy. Seven of the original 18 patients (39%) have continued to experience benefit from maintenance gabapentin treatment. Only three patients had to discontinue the gabapentin because of side effects. None of the 18 patients experienced an obvious significant adverse drug-drug interaction. Five of the patients discontinued gabapentin because of diminished clinical efficacy after a significant period of positive therapeutic effect. The results of this small open study suggest that gabapentin may be effective as an augmenting agent in the maintenance phase of treatment of some bipolar spectrum patients.
C B Schaffer; L C Schaffer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of affective disorders     Volume:  55     ISSN:  0165-0327     ISO Abbreviation:  J Affect Disord     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-04-21     Completed Date:  2000-04-21     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  237-40     Citation Subset:  IM    
Department of Psychiatry, UC Davis School of Medicine, Sacramento, CA 95816, USA.
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MeSH Terms
Acetates / adverse effects,  pharmacology,  therapeutic use*
Acute Disease
Antimanic Agents / adverse effects,  pharmacology,  therapeutic use*
Bipolar Disorder / drug therapy*,  psychology
Cyclohexanecarboxylic Acids*
Follow-Up Studies
Middle Aged
Treatment Outcome
gamma-Aminobutyric Acid*
Reg. No./Substance:
0/Acetates; 0/Amines; 0/Antimanic Agents; 0/Cyclohexanecarboxylic Acids; 56-12-2/gamma-Aminobutyric Acid; 6CW7F3G59X/gabapentin

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