Document Detail

Open lung in ARDS.
MedLine Citation:
PMID:  14653963     Owner:  NLM     Status:  MEDLINE    
Every year, millions of patients worldwide receive ventilator support during surgery. Mechanical ventilation has become an important therapy in the treatment of patients with impaired pulmonary function and particularly in patients suffering from adult respiratory distress syndrome (ARDS). ARDS is caused by multiple factors and is characterized by respiratory dysfunction including hypoxemia and decreased lung compliance. It is known that the decrease in lung distensibility is due to a disturbed surfactant system with an elevated surface tension. This increase in surface tension leads to an increase in forces acting at the air-liquid interface, resulting finally in end-expiratory collapse, atelectasis, an increase in right-to-left shunt and a decrease in paO2.
Jack J Haitsma; Robert A Lachmann; Burkhard Lachmann
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta pharmacologica Sinica     Volume:  24     ISSN:  1671-4083     ISO Abbreviation:  Acta Pharmacol. Sin.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-05     Completed Date:  2004-08-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100956087     Medline TA:  Acta Pharmacol Sin     Country:  China    
Other Details:
Languages:  eng     Pagination:  1304-7     Citation Subset:  IM    
Deptartment of Anesthesiology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
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MeSH Terms
Positive-Pressure Respiration*
Respiratory Distress Syndrome, Adult / physiopathology,  therapy*
Respiratory Mechanics

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