| Open low-field magnetic resonance imaging in radiation therapy treatment planning. | |
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MedLine Citation:
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PMID: 12128138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the possibilities of an open low-field magnetic resonance imaging (MRI) scanner in external beam radiotherapy treatment (RT) planning. METHODS AND MATERIALS: A custom-made flat tabletop was constructed for the open MR, which was compatible with standard therapy positioning devices. To assess and correct image distortion in low-field MRI, a custom-made phantom was constructed and a software algorithm was developed. A total of 243 patients (43 patients with non-small-cell lung cancer, 155 patients with prostate cancer, and 45 patients with brain tumors) received low-field MR imaging in addition to computed tomographic (CT) planning imaging between January 1998 and September 2001 before the start of the irradiation. RESULTS: Open low-field MRI provided adequate images for RT planning in nearly 95% of the examined patients. The mean and the maximal distortions 15 cm around the isocenter were reduced from 2.5 mm to 0.9 mm and from 6.1 mm to 2.1 mm respectively. The MRI-assisted planning led to better discrimination of tumor extent in two-thirds of the patients and to an optimization in lung cancer RT planning in one-third of the patients. In prostate cancer planning, low-field MRI resulted in significant reduction (40%) of organ volume and clinical target volume (CTV) compared with CT and to a reduction of the mean percentage of rectal dose of 15%. In brain tumors, low-field MR image quality was superior compared with CT in 39/45 patients for planning purposes. CONCLUSIONS: The data presented here show that low-field MRI is feasible in RT treatment planning when image correction regarding system-induced distortions is performed and by selecting MR imaging protocol parameters with the emphasis on adequate images for RT planning. |
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Authors:
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Robert C Krempien; Kai Schubert; Dietmar Zierhut; Michael C Steckner; Martina Treiber; Wolfgang Harms; Ulrich Mende; Detlev Latz; Michael Wannenmacher; Frederik Wenz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 53 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-07-19 Completed Date: 2002-08-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 1350-60 Citation Subset: IM |
Affiliation:
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Department of Clinical Radiology, University of Heidelberg, Heidelberg, Germany. robertkrempien@med.uni-heidelberg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Brain Neoplasms / radiotherapy* Equipment Design Female Humans Lung Neoplasms / radiotherapy* Magnetic Resonance Imaging / methods* Male Models, Statistical Phantoms, Imaging Prostatic Neoplasms / radiotherapy* Radiotherapy Planning, Computer-Assisted / methods* Software Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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